Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi
The incidence of Alzheimer”s disease (AD) is expected to increase exponentially as the population ages. Continuing research in this area is essential to better understand this disease and develop strategies for prevention and treatment. Recent genome-wide association studies have identified several...
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| Format: | Book Section |
| Language: | English |
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Institute of Graduate Studies, UiTM
2014
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| Online Access: | https://ir.uitm.edu.my/id/eprint/19626/ |
| _version_ | 1848804816134864896 |
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| author | Samat @ Darawi, Mohd Nazif |
| author_facet | Samat @ Darawi, Mohd Nazif |
| author_sort | Samat @ Darawi, Mohd Nazif |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | The incidence of Alzheimer”s disease (AD) is expected to increase exponentially as the population ages. Continuing research in this area is essential to better understand this disease and develop strategies for prevention and treatment. Recent genome-wide association studies have identified several novel loci as genetic risk factors of AD. Previous studies also suggest the total plasma homocysteine (tHcy) level and its biological determinants such as folate and vitamin B12 contribute to the risk of AD. Some of them highlight the correlation between AD risk and genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and transcobalamin (TCN II) since they are directly associated with the Hcy metabolism. |
| first_indexed | 2025-11-14T22:01:09Z |
| format | Book Section |
| id | uitm-19626 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T22:01:09Z |
| publishDate | 2014 |
| publisher | Institute of Graduate Studies, UiTM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-196262018-06-07T03:05:20Z https://ir.uitm.edu.my/id/eprint/19626/ Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi Samat @ Darawi, Mohd Nazif Malaysia The incidence of Alzheimer”s disease (AD) is expected to increase exponentially as the population ages. Continuing research in this area is essential to better understand this disease and develop strategies for prevention and treatment. Recent genome-wide association studies have identified several novel loci as genetic risk factors of AD. Previous studies also suggest the total plasma homocysteine (tHcy) level and its biological determinants such as folate and vitamin B12 contribute to the risk of AD. Some of them highlight the correlation between AD risk and genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and transcobalamin (TCN II) since they are directly associated with the Hcy metabolism. Institute of Graduate Studies, UiTM 2014 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/19626/1/ABS_MOHD%20NAZIF%20SAMAT%20%40%20DARAWI%20TDRA%20VOL%206%20IGS_14.pdf Samat @ Darawi, Mohd Nazif (2014) Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi. (2014) In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam. |
| spellingShingle | Malaysia Samat @ Darawi, Mohd Nazif Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi |
| title | Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi |
| title_full | Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi |
| title_fullStr | Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi |
| title_full_unstemmed | Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi |
| title_short | Development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / Mohd Nazif Samat @ Darawi |
| title_sort | development of an allele-specific polymerase chain reaction genotyping test and association of selected single nucleotide polymorphisms and analytes with the risk of alzheimer’s disease / mohd nazif samat @ darawi |
| topic | Malaysia |
| url | https://ir.uitm.edu.my/id/eprint/19626/ |