Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim
Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppress...
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| Format: | Book Section |
| Language: | English |
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Institute of Graduate Studies, UiTM
2014
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| Online Access: | https://ir.uitm.edu.my/id/eprint/19615/ |
| _version_ | 1848804814258962432 |
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| author | Ibrahim, Hisham Saleh |
| author_facet | Ibrahim, Hisham Saleh |
| author_sort | Ibrahim, Hisham Saleh |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppression leads to increased blood pressure and endothelial activation. Therefore, this study investigated the effect of leptin and xanthenone (ACE2 activator) administration on systolic blood pressure (SBP), proteinuria and serum markers of endothelial activation during pregnancy in Sprague-Dawley rats. Eighty female Sprague-Dawley rats, aged 12- 13 weeks were randomised into 10 groups, Group 1 acted as a control non-pregnant group and given saline (NSNP). |
| first_indexed | 2025-11-14T22:01:07Z |
| format | Book Section |
| id | uitm-19615 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T22:01:07Z |
| publishDate | 2014 |
| publisher | Institute of Graduate Studies, UiTM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-196152018-06-07T02:42:49Z https://ir.uitm.edu.my/id/eprint/19615/ Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim Ibrahim, Hisham Saleh Malaysia Raised leptin levels have been reported in placentae and serum of women with elevated blood pressure and proteinuria during pregnancy. The role of leptin in this however remains unclear. ACE2 is a new member in RAAS, which is reported to have hypotensive and anti-inflammatory effect and its suppression leads to increased blood pressure and endothelial activation. Therefore, this study investigated the effect of leptin and xanthenone (ACE2 activator) administration on systolic blood pressure (SBP), proteinuria and serum markers of endothelial activation during pregnancy in Sprague-Dawley rats. Eighty female Sprague-Dawley rats, aged 12- 13 weeks were randomised into 10 groups, Group 1 acted as a control non-pregnant group and given saline (NSNP). Institute of Graduate Studies, UiTM 2014 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/19615/1/ABS_HISHAM%20SALEH%20IBRAHIM%20TDRA%20VOL%206%20IGS_14.pdf Ibrahim, Hisham Saleh (2014) Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim. (2014) In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam. |
| spellingShingle | Malaysia Ibrahim, Hisham Saleh Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim |
| title | Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim |
| title_full | Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim |
| title_fullStr | Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim |
| title_full_unstemmed | Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim |
| title_short | Effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / Hisham Saleh Ibrahim |
| title_sort | effect of exogenous leptin on blood pressure, urinary protein excresion, endothelial activation and ace2 expression during pregnancy in the rat / hisham saleh ibrahim |
| topic | Malaysia |
| url | https://ir.uitm.edu.my/id/eprint/19615/ |