Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli
Leukaemia chemotherapy had advanced considerably, enabling higher rates of survival and cure. This success is largely attributable to optimization of the use of chemotherapeutic agents such as 6-mercaptopurine (6-MP). However challenges still remain in striking a delicate balance between therapeutic...
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| Format: | Book Section |
| Language: | English |
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Institute of Graduate Studies, UiTM
2012
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| Online Access: | https://ir.uitm.edu.my/id/eprint/19123/ |
| _version_ | 1848804690059329536 |
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| author | Wan Rosli, Wan Rosalina |
| author_facet | Wan Rosli, Wan Rosalina |
| author_sort | Wan Rosli, Wan Rosalina |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | Leukaemia chemotherapy had advanced considerably, enabling higher rates of survival and cure. This success is largely attributable to optimization of the use of chemotherapeutic agents such as 6-mercaptopurine (6-MP). However challenges still remain in striking a delicate balance between therapeutic outcome and risk of toxicity due to the narrow therapeutic window of anticancer drugs. This is compounded by the variability in patient response even when given the standard dose. Identification of patients at risk of adverse events would be beneficial, thus pharmacogenomics could play a role in reducing the related adverse drug reaction and hospitalization by the development of diagnostic tools to tailor appropriate therapies for patients. |
| first_indexed | 2025-11-14T21:59:08Z |
| format | Book Section |
| id | uitm-19123 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:59:08Z |
| publishDate | 2012 |
| publisher | Institute of Graduate Studies, UiTM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-191232018-06-11T02:39:11Z https://ir.uitm.edu.my/id/eprint/19123/ Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli Wan Rosli, Wan Rosalina Malaysia Cancer Leukaemia chemotherapy had advanced considerably, enabling higher rates of survival and cure. This success is largely attributable to optimization of the use of chemotherapeutic agents such as 6-mercaptopurine (6-MP). However challenges still remain in striking a delicate balance between therapeutic outcome and risk of toxicity due to the narrow therapeutic window of anticancer drugs. This is compounded by the variability in patient response even when given the standard dose. Identification of patients at risk of adverse events would be beneficial, thus pharmacogenomics could play a role in reducing the related adverse drug reaction and hospitalization by the development of diagnostic tools to tailor appropriate therapies for patients. Institute of Graduate Studies, UiTM 2012 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/19123/1/ABS_WAN%20ROSALINA%20WAN%20ROSLI%20TDRA%20VOL%201%20IGS%2012.pdf Wan Rosli, Wan Rosalina (2012) Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli. (2012) In: The Doctoral Research Abstracts. IPSis Biannual Publication, 1 (1). Institute of Graduate Studies, UiTM, Shah Alam. |
| spellingShingle | Malaysia Cancer Wan Rosli, Wan Rosalina Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli |
| title | Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli |
| title_full | Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli |
| title_fullStr | Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli |
| title_full_unstemmed | Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli |
| title_short | Understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (All) patients treated with 6-mercaptopurine (6-Mp): a pharmacogenomics-metabolomics perspective / Wan Rosalina Wan Rosli |
| title_sort | understanding interpatient variation of clinical responses among acute lymphoblastic leukaemia (all) patients treated with 6-mercaptopurine (6-mp): a pharmacogenomics-metabolomics perspective / wan rosalina wan rosli |
| topic | Malaysia Cancer |
| url | https://ir.uitm.edu.my/id/eprint/19123/ |