The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa
In the present study, the cardiovascular effect of Tinospora crispa extracts on the isolated paced left atrium, spontaneously beating right atrium and the descending aorta of rats were studied. The stems of T.crispa were serially extracted with petroleum ether, followed by chloroform, methanol and l...
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| Format: | Article |
| Language: | English |
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Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA)
2010
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| Online Access: | https://ir.uitm.edu.my/id/eprint/16497/ |
| _version_ | 1848804024328912896 |
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| author | Bakhari, Nor Aziyah Isa, Norain |
| author_facet | Bakhari, Nor Aziyah Isa, Norain |
| author_sort | Bakhari, Nor Aziyah |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | In the present study, the cardiovascular effect of Tinospora crispa extracts on the isolated paced left atrium, spontaneously beating right atrium and the descending aorta of rats were studied. The stems of T.crispa were serially extracted with petroleum ether, followed by chloroform, methanol and lastly water. The chloroform extract caused the strongest inhibition on the inotropic effect of isoprenaline (ISP) to the left atrium. The inhibition was non-competetive since the maximum of the log dose-response curve of the atrium to ISP was reduced. However, none of the extracts (0.2-1.0 mg/mL) significantly influenced the inotropic activity of the right atrium to ISP All the extracts studied also non-competetively inhibited the noradrenaline (NA)-induced rat aortic strips contraction and the chloroform extract was again found to be the most potent extract. The chloroform extract was therefore fractionated and the effect of the fractions on the NA-induced rat aortic strips contraction was examined. CF3 fraction was found to be the most active fraction and was further fractionated. The fractions were tested again on the NA-induced rat aortic strips contraction. However, all fractions showed almost the same effect where 0.50 mg/mL fractions reduced the maximum response by about 60-80%. |
| first_indexed | 2025-11-14T21:48:34Z |
| format | Article |
| id | uitm-16497 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:48:34Z |
| publishDate | 2010 |
| publisher | Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) |
| recordtype | eprints |
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| spelling | uitm-164972019-11-18T07:33:05Z https://ir.uitm.edu.my/id/eprint/16497/ The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa esteem Bakhari, Nor Aziyah Isa, Norain In the present study, the cardiovascular effect of Tinospora crispa extracts on the isolated paced left atrium, spontaneously beating right atrium and the descending aorta of rats were studied. The stems of T.crispa were serially extracted with petroleum ether, followed by chloroform, methanol and lastly water. The chloroform extract caused the strongest inhibition on the inotropic effect of isoprenaline (ISP) to the left atrium. The inhibition was non-competetive since the maximum of the log dose-response curve of the atrium to ISP was reduced. However, none of the extracts (0.2-1.0 mg/mL) significantly influenced the inotropic activity of the right atrium to ISP All the extracts studied also non-competetively inhibited the noradrenaline (NA)-induced rat aortic strips contraction and the chloroform extract was again found to be the most potent extract. The chloroform extract was therefore fractionated and the effect of the fractions on the NA-induced rat aortic strips contraction was examined. CF3 fraction was found to be the most active fraction and was further fractionated. The fractions were tested again on the NA-induced rat aortic strips contraction. However, all fractions showed almost the same effect where 0.50 mg/mL fractions reduced the maximum response by about 60-80%. Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2010 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/16497/1/AJ_NOR%20AZIYAH%20BAKHARI%20ESTEEM%2010.pdf Bakhari, Nor Aziyah and Isa, Norain (2010) The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa. (2010) Esteem Academic Journal <https://ir.uitm.edu.my/view/publication/Esteem_Academic_Journal.html>, 6 (2). pp. 141-150. ISSN 1675-7939 |
| spellingShingle | Bakhari, Nor Aziyah Isa, Norain The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa |
| title | The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa |
| title_full | The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa |
| title_fullStr | The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa |
| title_full_unstemmed | The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa |
| title_short | The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa |
| title_sort | effect of tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / nor aziyah bakhari and norain isa |
| url | https://ir.uitm.edu.my/id/eprint/16497/ |