Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized throu...
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| Format: | Article |
| Language: | English |
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Research Management Institute (RMI)
2010
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| Online Access: | https://ir.uitm.edu.my/id/eprint/12932/ |
| _version_ | 1848803203563388928 |
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| author | Ahmad, Faujan |
| author_facet | Ahmad, Faujan |
| author_sort | Ahmad, Faujan |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized through the reaction of betulinic acid with benzoyl chloride and acetic anhydride using a lipase catalyst. Enzyme-catalyzed reaction of betulinic acid with benzoyl chloride yielded 3B-benzoil-lup-20(29)-ene-28-oic acid ester (BCL), whereas the acetic anhydride reaction yielded 3B-acetoxy-lup-20(29)-ene-28-oic acid ester (BAA). The BAA underwent further reaction with l-decanol to produce 3B-acetoxy-lup-20(29)-ene-28 decanoate (BAAD). The prepared betulinic acid derivatives were tested for cytotoxic activity on three callcer cell lines in vitro: all tested compunds showed greater activity than betulinic acid. |
| first_indexed | 2025-11-14T21:35:31Z |
| format | Article |
| id | uitm-12932 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:35:31Z |
| publishDate | 2010 |
| publisher | Research Management Institute (RMI) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-129322019-03-28T02:45:20Z https://ir.uitm.edu.my/id/eprint/12932/ Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad srj Ahmad, Faujan Enzymes Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized through the reaction of betulinic acid with benzoyl chloride and acetic anhydride using a lipase catalyst. Enzyme-catalyzed reaction of betulinic acid with benzoyl chloride yielded 3B-benzoil-lup-20(29)-ene-28-oic acid ester (BCL), whereas the acetic anhydride reaction yielded 3B-acetoxy-lup-20(29)-ene-28-oic acid ester (BAA). The BAA underwent further reaction with l-decanol to produce 3B-acetoxy-lup-20(29)-ene-28 decanoate (BAAD). The prepared betulinic acid derivatives were tested for cytotoxic activity on three callcer cell lines in vitro: all tested compunds showed greater activity than betulinic acid. Research Management Institute (RMI) 2010 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/12932/1/AJ_YAMIN%20YASIN%20SRJ%2010%20%282%29.pdf Ahmad, Faujan (2010) Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad. (2010) Scientific Research Journal <https://ir.uitm.edu.my/view/publication/Scientific_Research_Journal.html>, 7 (1). pp. 65-76. ISSN 1675-7009 https://srj.uitm.edu.my/ |
| spellingShingle | Enzymes Ahmad, Faujan Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad |
| title | Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad |
| title_full | Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad |
| title_fullStr | Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad |
| title_full_unstemmed | Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad |
| title_short | Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad |
| title_sort | lipase catalyzed betulinic acid derivatives and its cytotoxic activity / yamin yasin and faujan ahmad |
| topic | Enzymes |
| url | https://ir.uitm.edu.my/id/eprint/12932/ https://ir.uitm.edu.my/id/eprint/12932/ |