In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2
Four binuclear phosphanesilver(I) dithiocarbamates, {cyclohexyl3PAg(S2CNRR′)}2 for R = R′ = Et (1), CH2CH2 (2), CH2CH2OH (3) and R = Me, R′ = CH2CH2OH (4) have been synthesised and characterised by spectroscopy and crystallography, and feature tri-connective, μ2-bridging dithiocarbamate ligands and...
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Elsevier
2019
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| Online Access: | http://eprints.sunway.edu.my/989/ http://eprints.sunway.edu.my/989/1/Tiekink%20In%20vitro%20JInorgBiochem%20192%20%282019%29%20107.pdf |
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| author | Tan, Yi Jiun * Tan, Yee Seng * Yeo, Chien Ing * Chew, Jactty * Tiekink, Edward R. T. * |
| author_facet | Tan, Yi Jiun * Tan, Yee Seng * Yeo, Chien Ing * Chew, Jactty * Tiekink, Edward R. T. * |
| author_sort | Tan, Yi Jiun * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Four binuclear phosphanesilver(I) dithiocarbamates, {cyclohexyl3PAg(S2CNRR′)}2 for R = R′ = Et (1), CH2CH2 (2), CH2CH2OH (3) and R = Me, R′ = CH2CH2OH (4) have been synthesised and characterised by spectroscopy and crystallography, and feature tri-connective, μ2-bridging dithiocarbamate ligands and distorted tetrahedral geometries based on PS3 donor sets. The compounds were evaluated for anti-bacterial activity against a total of 12 clinically important pathogens. Based on minimum inhibitory concentration (MIC) and cell viability tests (human embryonic kidney cells, HEK 293), 1–4 are specifically active against Gram-positive bacteria while demonstrating low toxicity; 3 and 4 are active against methicillin resistant S. aureus (MRSA). Across the series, 4 was most effective and was more active than the standard anti-biotic chloramphenicol. Time kill assays reveal 1–4 to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Compound 4 demonstrates rapid (within 2 h) bactericidal activity at 1 and 2 × MIC to reach a maximum decrease of 5.2 log10 CFU/mL against S. aureus (MRSA). |
| first_indexed | 2025-11-14T21:15:50Z |
| format | Article |
| id | sunway-989 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:15:50Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-9892020-10-12T07:46:04Z http://eprints.sunway.edu.my/989/ In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2 Tan, Yi Jiun * Tan, Yee Seng * Yeo, Chien Ing * Chew, Jactty * Tiekink, Edward R. T. * QD Chemistry Four binuclear phosphanesilver(I) dithiocarbamates, {cyclohexyl3PAg(S2CNRR′)}2 for R = R′ = Et (1), CH2CH2 (2), CH2CH2OH (3) and R = Me, R′ = CH2CH2OH (4) have been synthesised and characterised by spectroscopy and crystallography, and feature tri-connective, μ2-bridging dithiocarbamate ligands and distorted tetrahedral geometries based on PS3 donor sets. The compounds were evaluated for anti-bacterial activity against a total of 12 clinically important pathogens. Based on minimum inhibitory concentration (MIC) and cell viability tests (human embryonic kidney cells, HEK 293), 1–4 are specifically active against Gram-positive bacteria while demonstrating low toxicity; 3 and 4 are active against methicillin resistant S. aureus (MRSA). Across the series, 4 was most effective and was more active than the standard anti-biotic chloramphenicol. Time kill assays reveal 1–4 to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Compound 4 demonstrates rapid (within 2 h) bactericidal activity at 1 and 2 × MIC to reach a maximum decrease of 5.2 log10 CFU/mL against S. aureus (MRSA). Elsevier 2019-01-06 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/989/1/Tiekink%20In%20vitro%20JInorgBiochem%20192%20%282019%29%20107.pdf Tan, Yi Jiun * and Tan, Yee Seng * and Yeo, Chien Ing * and Chew, Jactty * and Tiekink, Edward R. T. * (2019) In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2. Journal of Inorganic Biochemistry, 192. pp. 107-118. ISSN 0162-0134 http://doi.org/10.1016/j.jinorgbio.2018.12.017 doi:10.1016/j.jinorgbio.2018.12.017 |
| spellingShingle | QD Chemistry Tan, Yi Jiun * Tan, Yee Seng * Yeo, Chien Ing * Chew, Jactty * Tiekink, Edward R. T. * In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2 |
| title | In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2 |
| title_full | In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2 |
| title_fullStr | In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2 |
| title_full_unstemmed | In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2 |
| title_short | In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2 |
| title_sort | in vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(i) dithiocarbamates, {cy3pag(s2cnrr′)}2 |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/989/ http://eprints.sunway.edu.my/989/ http://eprints.sunway.edu.my/989/ http://eprints.sunway.edu.my/989/1/Tiekink%20In%20vitro%20JInorgBiochem%20192%20%282019%29%20107.pdf |