One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism
A highly selective and efficient method for the synthesis of 3,3’(5,5’)-polymethylene-bis(1H1,2,4-triazol-5(3)-amines) was developed using the reaction of dicarboxylic acids and aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the des...
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Online Access: | http://eprints.sunway.edu.my/909/ http://eprints.sunway.edu.my/909/1/Tiekink%20One%20pot%20microwave.pdf |
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| author | Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V |
| author_facet | Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V |
| author_sort | Phei, Felicia Lin Lim |
| building | SU Institutional Repository |
| collection | Online Access |
| description | A highly selective and efficient method for the synthesis of 3,3’(5,5’)-polymethylene-bis(1H1,2,4-triazol-5(3)-amines)
was developed using the reaction of dicarboxylic acids and
aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the desired products in good yields and purity. The scope of the method was successfully explored by the preparation of a small library of polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) with different alkyl chain linkers. The annular prototropic tautomerism in the prepared compounds was studied using NMR spectroscopy and X-ray crystallography. |
| first_indexed | 2025-11-14T21:15:13Z |
| format | Article |
| id | sunway-909 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:15:13Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-9092020-10-07T09:21:39Z http://eprints.sunway.edu.my/909/ One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V QD Chemistry A highly selective and efficient method for the synthesis of 3,3’(5,5’)-polymethylene-bis(1H1,2,4-triazol-5(3)-amines) was developed using the reaction of dicarboxylic acids and aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the desired products in good yields and purity. The scope of the method was successfully explored by the preparation of a small library of polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) with different alkyl chain linkers. The annular prototropic tautomerism in the prepared compounds was studied using NMR spectroscopy and X-ray crystallography. Elsevier 2018 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/909/1/Tiekink%20One%20pot%20microwave.pdf Phei, Felicia Lin Lim and Lee, Ming Hu and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2018) One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism. Tetrahedron Letters, 59 (42). pp. 3792-3796. ISSN 0040-4039 http://www.elsevier.com |
| spellingShingle | QD Chemistry Phei, Felicia Lin Lim Lee, Ming Hu Tiekink, Edward R. T. * Dolzhenko, Anton V One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
| title | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
| title_full | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
| title_fullStr | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
| title_full_unstemmed | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
| title_short | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism |
| title_sort | one-pot, microwave-assisted synthesis of polymethylene-bridged bis(1h-1,2,4triazol-5(3)-amines) and their tautomerism |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/909/ http://eprints.sunway.edu.my/909/ http://eprints.sunway.edu.my/909/1/Tiekink%20One%20pot%20microwave.pdf |