A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a] [1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanam...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2018
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| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/842/ http://eprints.sunway.edu.my/842/1/Tieknink%20One%20Pot%20multicomponent.pdf |
| _version_ | 1848801908933787648 |
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| author | Lim, Felicia Phei Lin Tan, Lin Yuing Tiekink, Edward R. T. * Dolzhenko, Anton V |
| author_facet | Lim, Felicia Phei Lin Tan, Lin Yuing Tiekink, Edward R. T. * Dolzhenko, Anton V |
| author_sort | Lim, Felicia Phei Lin |
| building | SU Institutional Repository |
| collection | Online Access |
| description | A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a]
[1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the
structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently
performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography. |
| first_indexed | 2025-11-14T21:14:56Z |
| format | Article |
| id | sunway-842 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:14:56Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-8422020-10-07T09:05:47Z http://eprints.sunway.edu.my/842/ A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines Lim, Felicia Phei Lin Tan, Lin Yuing Tiekink, Edward R. T. * Dolzhenko, Anton V QD Chemistry A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a] [1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography. Royal Society of Chemistry 2018-06-12 Article PeerReviewed text en http://eprints.sunway.edu.my/842/1/Tieknink%20One%20Pot%20multicomponent.pdf Lim, Felicia Phei Lin and Tan, Lin Yuing and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2018) A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines. RSC Advances, 8 (38). pp. 21495-21504. ISSN 2046-2069 http://doi.org/10.1039/c8ra03703e doi:10.1039/c8ra03703e |
| spellingShingle | QD Chemistry Lim, Felicia Phei Lin Tan, Lin Yuing Tiekink, Edward R. T. * Dolzhenko, Anton V A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines |
| title | A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines |
| title_full | A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines |
| title_fullStr | A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines |
| title_full_unstemmed | A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines |
| title_short | A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines |
| title_sort | one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/842/ http://eprints.sunway.edu.my/842/ http://eprints.sunway.edu.my/842/ http://eprints.sunway.edu.my/842/1/Tieknink%20One%20Pot%20multicomponent.pdf |