Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes se...
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| Format: | Article |
| Language: | English |
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IvySpring International Publisher
2017
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| Online Access: | http://eprints.sunway.edu.my/832/ http://eprints.sunway.edu.my/832/1/Ronald%20Teow%20Pathogenic%20role%20of%20exosomes.pdf |
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| author | Teow, Sin Yeang * Liew, Kitson Khoo, Alan Soo Beng Peh, Suat Cheng * |
| author_facet | Teow, Sin Yeang * Liew, Kitson Khoo, Alan Soo Beng Peh, Suat Cheng * |
| author_sort | Teow, Sin Yeang * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular
cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes serve as key mediators in intercellular communication by facilitating the transfer and
exchange of cellular components from cells to cells. They contain various pathogenic factors whereby their adverse effects have been implicated in multiple viral infections and cancers. Interestingly, accumulating evidences showed that exosomes derived from tumour viruses or
oncoviruses, exacerbate virus-associated cancers by remodelling the tumour microenvironment. In this review, we summarize the contributing factors of Epstein-Barr virus (EBV) products-containing exosomes in viral pathogenesis and their potential implications in EBV-driven
malignancies. Understanding the biological role of these exosomes in the disease would undoubtedly boost the development of a more comprehensive strategy to combat EBV-associated cancers and to better predict the therapeutic outcomes. Furthermore, we also highlight the potentials and challenges of EBV products-containing exosomes being employed as diagnostic markers and therapeutic targets for EBV-related cancers. Since these aspects are rather
underexplored, we attempt to underline interesting areas that warrant further investigations in the future. |
| first_indexed | 2025-11-14T21:14:54Z |
| format | Article |
| id | sunway-832 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:14:54Z |
| publishDate | 2017 |
| publisher | IvySpring International Publisher |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-8322019-06-03T02:31:26Z http://eprints.sunway.edu.my/832/ Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers Teow, Sin Yeang * Liew, Kitson Khoo, Alan Soo Beng Peh, Suat Cheng * RC0254 Neoplasms. Tumors. Oncology (including Cancer) Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. They contain various pathogenic factors whereby their adverse effects have been implicated in multiple viral infections and cancers. Interestingly, accumulating evidences showed that exosomes derived from tumour viruses or oncoviruses, exacerbate virus-associated cancers by remodelling the tumour microenvironment. In this review, we summarize the contributing factors of Epstein-Barr virus (EBV) products-containing exosomes in viral pathogenesis and their potential implications in EBV-driven malignancies. Understanding the biological role of these exosomes in the disease would undoubtedly boost the development of a more comprehensive strategy to combat EBV-associated cancers and to better predict the therapeutic outcomes. Furthermore, we also highlight the potentials and challenges of EBV products-containing exosomes being employed as diagnostic markers and therapeutic targets for EBV-related cancers. Since these aspects are rather underexplored, we attempt to underline interesting areas that warrant further investigations in the future. IvySpring International Publisher 2017-09-21 Article PeerReviewed text en http://eprints.sunway.edu.my/832/1/Ronald%20Teow%20Pathogenic%20role%20of%20exosomes.pdf Teow, Sin Yeang * and Liew, Kitson and Khoo, Alan Soo Beng and Peh, Suat Cheng * (2017) Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers. International Journal of Biological Sciences, 13 (10). pp. 1276-1286. ISSN 1449-2288 http://www.ijbs.com doi:10.7150/ijbs.19531 |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Teow, Sin Yeang * Liew, Kitson Khoo, Alan Soo Beng Peh, Suat Cheng * Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers |
| title | Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers |
| title_full | Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers |
| title_fullStr | Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers |
| title_full_unstemmed | Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers |
| title_short | Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers |
| title_sort | pathogenic role of exosomes in epstein-barr virus (ebv)-associated cancers |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/832/ http://eprints.sunway.edu.my/832/ http://eprints.sunway.edu.my/832/ http://eprints.sunway.edu.my/832/1/Ronald%20Teow%20Pathogenic%20role%20of%20exosomes.pdf |