Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers
Exosomes are microvesicles with sizes ranging from 50 to 150 nm. These small vesicles are known to morphologically and functionally resemble virus particles from human immunodeficiency virus type I (HIV-I) and human T-lymphotropic virus type I (HTLV-I). The function of exosomes is to mainly mediate...
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| Format: | Book Section |
| Language: | English |
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InTech Open Publisher
2017
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| Online Access: | http://eprints.sunway.edu.my/828/ http://eprints.sunway.edu.my/828/1/Ronald%20Teow%20Exosomes%20as%20the%20promising.pdf |
| _version_ | 1848801905138991104 |
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| author | Teow, Sin Yeang * Peh, Suat Cheng * |
| author2 | Wang, Jin |
| author_facet | Wang, Jin Teow, Sin Yeang * Peh, Suat Cheng * |
| author_sort | Teow, Sin Yeang * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Exosomes are microvesicles with sizes ranging from 50 to 150 nm. These small vesicles are known to morphologically and functionally resemble virus particles from human immunodeficiency virus type I (HIV-I) and human T-lymphotropic virus type I (HTLV-I). The function of exosomes is to mainly mediate cell-to-cell communication by exchanging various macromolecules including proteins, lipids and nucleic acids in diverse cellular processes. Due to its size and structural simplicity, the transfer of pathogenic or virulent cellular factors across the cells mediated by exosomes is more efficient, hence facilitating the dissemination of viral infections and cancer diseases. The pathogenic role of exosomes in various cancers such as lung and breast, and their potentials as biomarkers have been previously studied, yet limited information is known for Epstein-Barr virus (EBV)-associated cancers. In this chapter, we discuss current evidences that support the pathogenic roles of exosomes in EBV-related cancers and their potentials as biomarkers in cancer diagnostics and therapy response. Here, we also highlight the potential challenges in the development of exosome-based biomarkers for clinical application. |
| first_indexed | 2025-11-14T21:14:52Z |
| format | Book Section |
| id | sunway-828 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:14:52Z |
| publishDate | 2017 |
| publisher | InTech Open Publisher |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-8282021-03-24T06:10:54Z http://eprints.sunway.edu.my/828/ Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers Teow, Sin Yeang * Peh, Suat Cheng * RC0254 Neoplasms. Tumors. Oncology (including Cancer) Exosomes are microvesicles with sizes ranging from 50 to 150 nm. These small vesicles are known to morphologically and functionally resemble virus particles from human immunodeficiency virus type I (HIV-I) and human T-lymphotropic virus type I (HTLV-I). The function of exosomes is to mainly mediate cell-to-cell communication by exchanging various macromolecules including proteins, lipids and nucleic acids in diverse cellular processes. Due to its size and structural simplicity, the transfer of pathogenic or virulent cellular factors across the cells mediated by exosomes is more efficient, hence facilitating the dissemination of viral infections and cancer diseases. The pathogenic role of exosomes in various cancers such as lung and breast, and their potentials as biomarkers have been previously studied, yet limited information is known for Epstein-Barr virus (EBV)-associated cancers. In this chapter, we discuss current evidences that support the pathogenic roles of exosomes in EBV-related cancers and their potentials as biomarkers in cancer diagnostics and therapy response. Here, we also highlight the potential challenges in the development of exosome-based biomarkers for clinical application. InTech Open Publisher Wang, Jin 2017-07-12 Book Section PeerReviewed text en cc_by_nc http://eprints.sunway.edu.my/828/1/Ronald%20Teow%20Exosomes%20as%20the%20promising.pdf Teow, Sin Yeang * and Peh, Suat Cheng * (2017) Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers. In: Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases. InTech Open Publisher, pp. 97-114. ISBN 978 953 51 3336 0 http://doi.org/10.5772/intechopen.69532 doi:10.5772/intechopen.69532 |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Teow, Sin Yeang * Peh, Suat Cheng * Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers |
| title | Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers |
| title_full | Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers |
| title_fullStr | Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers |
| title_full_unstemmed | Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers |
| title_short | Exosomes as the promising biomarker for Epstein-Barr Virus (EBV)-associated cancers |
| title_sort | exosomes as the promising biomarker for epstein-barr virus (ebv)-associated cancers |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/828/ http://eprints.sunway.edu.my/828/ http://eprints.sunway.edu.my/828/ http://eprints.sunway.edu.my/828/1/Ronald%20Teow%20Exosomes%20as%20the%20promising.pdf |