Peptides as therapeutic agents for dengue virus
Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is therefore an urg...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2017
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| Online Access: | http://eprints.sunway.edu.my/669/ http://eprints.sunway.edu.my/669/1/Chew%20Miaw%20Fang%20Peptides%20as%20Therapeutics%20Agents%20for%20Dengue%20Virus.pdf |
| _version_ | 1848801874172444672 |
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| author | Chew, Miaw Fang * Poh, Keat Seong Poh, Chit Laa * |
| author_facet | Chew, Miaw Fang * Poh, Keat Seong Poh, Chit Laa * |
| author_sort | Chew, Miaw Fang * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is
therefore an urgent need for the development of antiviral drugs for the treatment of dengue. Peptide was once a neglected choice of medical treatment but it has lately regained interest from the pharmaceutical industry following pioneering advancements in technology. In this review, the design of peptide drugs, antiviral activities and mechanisms of peptides and peptidomimetics
(modified peptides) action against dengue virus are discussed. The development of peptides as
inhibitors for viral entry, replication and translation is also described, with a focus on the three
main targets, namely, the host cell receptors, viral structural proteins and viral non-structural
proteins. The antiviral peptides designed based on these approaches may lead to the discovery of
novel anti-DENV therapeutics that can treat dengue patients. |
| first_indexed | 2025-11-14T21:14:23Z |
| format | Article |
| id | sunway-669 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:14:23Z |
| publishDate | 2017 |
| publisher | Ivyspring International Publisher |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-6692019-04-22T05:06:17Z http://eprints.sunway.edu.my/669/ Peptides as therapeutic agents for dengue virus Chew, Miaw Fang * Poh, Keat Seong Poh, Chit Laa * QR355 Virology Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is therefore an urgent need for the development of antiviral drugs for the treatment of dengue. Peptide was once a neglected choice of medical treatment but it has lately regained interest from the pharmaceutical industry following pioneering advancements in technology. In this review, the design of peptide drugs, antiviral activities and mechanisms of peptides and peptidomimetics (modified peptides) action against dengue virus are discussed. The development of peptides as inhibitors for viral entry, replication and translation is also described, with a focus on the three main targets, namely, the host cell receptors, viral structural proteins and viral non-structural proteins. The antiviral peptides designed based on these approaches may lead to the discovery of novel anti-DENV therapeutics that can treat dengue patients. Ivyspring International Publisher 2017 Article PeerReviewed text en http://eprints.sunway.edu.my/669/1/Chew%20Miaw%20Fang%20Peptides%20as%20Therapeutics%20Agents%20for%20Dengue%20Virus.pdf Chew, Miaw Fang * and Poh, Keat Seong and Poh, Chit Laa * (2017) Peptides as therapeutic agents for dengue virus. International Journal of Medical Sciences, 14 (13). pp. 1342-1359. ISSN 1449-1907 |
| spellingShingle | QR355 Virology Chew, Miaw Fang * Poh, Keat Seong Poh, Chit Laa * Peptides as therapeutic agents for dengue virus |
| title | Peptides as therapeutic agents for dengue virus |
| title_full | Peptides as therapeutic agents for dengue virus |
| title_fullStr | Peptides as therapeutic agents for dengue virus |
| title_full_unstemmed | Peptides as therapeutic agents for dengue virus |
| title_short | Peptides as therapeutic agents for dengue virus |
| title_sort | peptides as therapeutic agents for dengue virus |
| topic | QR355 Virology |
| url | http://eprints.sunway.edu.my/669/ http://eprints.sunway.edu.my/669/1/Chew%20Miaw%20Fang%20Peptides%20as%20Therapeutics%20Agents%20for%20Dengue%20Virus.pdf |