New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases
Copper (II) complexes synthesized from the products of condensation of S-methyl- and S-benzyldithiocarbazate with 2,5-hexanedione (SMHDH2 and SBHDH2 respectively) have been characterized using various physicochemical (elemental analysis, molar conductivity, magnetic susceptibility) and spectroscopic...
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://eprints.sunway.edu.my/649/ http://eprints.sunway.edu.my/649/1/EurJMedChem%202016%20120%201.pdf |
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| author | Low, May Lee Maigre, Laure Mohamed, Ibrahim Mohamed Tahir Tiekink, Edward R. T. * Dorlet, Pierre Guillot, Régis Ravoof, Thahira Begum S. A. Rozita Rosli, Pagès, Jean-Marie Policar, Clotilde Delsuc, Nicolas Crouse, Karen A. |
| author_facet | Low, May Lee Maigre, Laure Mohamed, Ibrahim Mohamed Tahir Tiekink, Edward R. T. * Dorlet, Pierre Guillot, Régis Ravoof, Thahira Begum S. A. Rozita Rosli, Pagès, Jean-Marie Policar, Clotilde Delsuc, Nicolas Crouse, Karen A. |
| author_sort | Low, May Lee |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Copper (II) complexes synthesized from the products of condensation of S-methyl- and S-benzyldithiocarbazate with 2,5-hexanedione (SMHDH2 and SBHDH2 respectively) have been characterized using various physicochemical (elemental analysis, molar conductivity, magnetic susceptibility) and spectroscopic (infrared, electronic) methods. The structures of SMHDH2, its copper (II) complex, CuSMHD, and the related CuSBHD complex as well as a pyrrole byproduct, SBPY, have been determined by single crystal X-ray diffraction. In order to provide more insight into the behaviour of the complexes in solution, electron paramagnetic resonance (EPR) and electrochemical experiments were performed. Antibacterial activity and cytotoxicity were evaluated. The compounds, dissolved in 0.5% and 5% DMSO, showed a wide range of antibacterial activity against 10 strains of Gram-positive and Gram-negative bacteria. Investigations of the effects of efflux pumps and membrane penetration on antibacterial activity are reported herein. Antiproliferation activity was observed to be enhanced by complexation with copper. Preliminary screening showed Cu complexes are strongly active against human breast adenocarcinoma cancer cell lines MDA-MB-231 and MCF-7. |
| first_indexed | 2025-11-14T21:14:18Z |
| format | Article |
| id | sunway-649 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:14:18Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-6492020-10-07T09:48:52Z http://eprints.sunway.edu.my/649/ New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases Low, May Lee Maigre, Laure Mohamed, Ibrahim Mohamed Tahir Tiekink, Edward R. T. * Dorlet, Pierre Guillot, Régis Ravoof, Thahira Begum S. A. Rozita Rosli, Pagès, Jean-Marie Policar, Clotilde Delsuc, Nicolas Crouse, Karen A. QD Chemistry Copper (II) complexes synthesized from the products of condensation of S-methyl- and S-benzyldithiocarbazate with 2,5-hexanedione (SMHDH2 and SBHDH2 respectively) have been characterized using various physicochemical (elemental analysis, molar conductivity, magnetic susceptibility) and spectroscopic (infrared, electronic) methods. The structures of SMHDH2, its copper (II) complex, CuSMHD, and the related CuSBHD complex as well as a pyrrole byproduct, SBPY, have been determined by single crystal X-ray diffraction. In order to provide more insight into the behaviour of the complexes in solution, electron paramagnetic resonance (EPR) and electrochemical experiments were performed. Antibacterial activity and cytotoxicity were evaluated. The compounds, dissolved in 0.5% and 5% DMSO, showed a wide range of antibacterial activity against 10 strains of Gram-positive and Gram-negative bacteria. Investigations of the effects of efflux pumps and membrane penetration on antibacterial activity are reported herein. Antiproliferation activity was observed to be enhanced by complexation with copper. Preliminary screening showed Cu complexes are strongly active against human breast adenocarcinoma cancer cell lines MDA-MB-231 and MCF-7. Elsevier 2016-09-14 Article PeerReviewed text en http://eprints.sunway.edu.my/649/1/EurJMedChem%202016%20120%201.pdf Low, May Lee and Maigre, Laure and Mohamed, Ibrahim Mohamed Tahir and Tiekink, Edward R. T. * and Dorlet, Pierre and Guillot, Régis and Ravoof, Thahira Begum S. A. and Rozita Rosli, and Pagès, Jean-Marie and Policar, Clotilde and Delsuc, Nicolas and Crouse, Karen A. (2016) New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases. European Journal of Medicinal Chemistry, 120. pp. 1-12. ISSN 02235234 http://dx.doi.org/10.1016/j.ejmech.2016.04.027 doi:10.1016/j.ejmech.2016.04.027 |
| spellingShingle | QD Chemistry Low, May Lee Maigre, Laure Mohamed, Ibrahim Mohamed Tahir Tiekink, Edward R. T. * Dorlet, Pierre Guillot, Régis Ravoof, Thahira Begum S. A. Rozita Rosli, Pagès, Jean-Marie Policar, Clotilde Delsuc, Nicolas Crouse, Karen A. New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases |
| title | New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases |
| title_full | New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases |
| title_fullStr | New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases |
| title_full_unstemmed | New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases |
| title_short | New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases |
| title_sort | new insight into the structural, electrochemical and biological aspects of macroacyclic cu(ii) complexes derived from s-substituted dithiocarbazate schiff bases |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/649/ http://eprints.sunway.edu.my/649/ http://eprints.sunway.edu.my/649/ http://eprints.sunway.edu.my/649/1/EurJMedChem%202016%20120%201.pdf |