In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimuminhibitory concentration (MIC) scores,...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/614/ http://eprints.sunway.edu.my/614/1/JInorgBiochem%202016%20163%2068_Deposited.pdf |
| _version_ | 1848801860942561280 |
|---|---|
| author | Chen, Bao-Jing Nazzatush Shimar Jamaludin, Khoo, Chai-Hoon See, Tian-Hong Sim, Jiun-Horng Cheah, Yoke-Kqueen Siti Nadiah Abdul Halim, Seng, Hoi-Ling * Tiekink, Edward R. T. * |
| author_facet | Chen, Bao-Jing Nazzatush Shimar Jamaludin, Khoo, Chai-Hoon See, Tian-Hong Sim, Jiun-Horng Cheah, Yoke-Kqueen Siti Nadiah Abdul Halim, Seng, Hoi-Ling * Tiekink, Edward R. T. * |
| author_sort | Chen, Bao-Jing |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et
(3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8)
and Gram negative (16) bacteria. Based on minimuminhibitory concentration (MIC) scores, compounds 1 and 2
were shown tobe specifically potent against Grampositive bacteriawhereas compounds 3 and, to a lesser extent,
4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus
(MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics
against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3
being especially potent after 8 h exposure; compounds 1 and 3were bactericidal againstMRSA. Compound 3 was
the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P.
vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial
agents, either broad range or against specific bacteria. |
| first_indexed | 2025-11-14T21:14:10Z |
| format | Article |
| id | sunway-614 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:14:10Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-6142020-10-07T09:59:54Z http://eprints.sunway.edu.my/614/ In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates Chen, Bao-Jing Nazzatush Shimar Jamaludin, Khoo, Chai-Hoon See, Tian-Hong Sim, Jiun-Horng Cheah, Yoke-Kqueen Siti Nadiah Abdul Halim, Seng, Hoi-Ling * Tiekink, Edward R. T. * QD Chemistry Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimuminhibitory concentration (MIC) scores, compounds 1 and 2 were shown tobe specifically potent against Grampositive bacteriawhereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3were bactericidal againstMRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria. Elsevier 2016 Article PeerReviewed text en http://eprints.sunway.edu.my/614/1/JInorgBiochem%202016%20163%2068_Deposited.pdf Chen, Bao-Jing and Nazzatush Shimar Jamaludin, and Khoo, Chai-Hoon and See, Tian-Hong and Sim, Jiun-Horng and Cheah, Yoke-Kqueen and Siti Nadiah Abdul Halim, and Seng, Hoi-Ling * and Tiekink, Edward R. T. * (2016) In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates. Journal of Inorganic Biochemistry, 163. pp. 68-80. ISSN 01620134 http://dx.doi.org/10.1016/j.jinorgbio.2016.08.002 doi:10.1016/j.jinorgbio.2016.08.002 |
| spellingShingle | QD Chemistry Chen, Bao-Jing Nazzatush Shimar Jamaludin, Khoo, Chai-Hoon See, Tian-Hong Sim, Jiun-Horng Cheah, Yoke-Kqueen Siti Nadiah Abdul Halim, Seng, Hoi-Ling * Tiekink, Edward R. T. * In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_full | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_fullStr | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_full_unstemmed | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_short | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_sort | in vitro antibacterial and time kill evaluation of mononuclear phosphanegold(i) dithiocarbamates |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/614/ http://eprints.sunway.edu.my/614/ http://eprints.sunway.edu.my/614/ http://eprints.sunway.edu.my/614/1/JInorgBiochem%202016%20163%2068_Deposited.pdf |