Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 envelope glycoprotein trimers on neutralizing antibody induction

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Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 envelope glycoprotein trimers on neutralizing antibody induction

Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to im...

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Bibliographic Details
Main Authors:	Crooks, Ema T, Osawa, Keiko, Tong, Tommy Yuh Koon *, Grimley, Samantha L, Dai, Yang D, Whalen, Robert G, Kulp, Daniel W, Menis, Sergey, Schief, William R, Binley, James M
Format:	Article
Language:	English
Published:	Elsevier 2017
Subjects:	Q Science (General) QR355 Virology
Online Access:	http://eprints.sunway.edu.my/479/ http://eprints.sunway.edu.my/479/1/Tommy%20Tong.pdf

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