Pathogenesis of microbial keratitis
Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and 2 protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye 3 susceptible to corneal pathogens. Among bacterial pathogens, the most common agents 4 responsible for ke...
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Elsevier
2016
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| Online Access: | http://eprints.sunway.edu.my/465/ http://eprints.sunway.edu.my/465/1/zz%20Lakhundi%2BSiddiqui%2BKhan%202016.%20Pathogenesis%20of.pdf |
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| author | Lakhundi, Sahreena Siddiqui, Ruqaiyyah Bano * Khan, Naveed Ahmed * |
| author_facet | Lakhundi, Sahreena Siddiqui, Ruqaiyyah Bano * Khan, Naveed Ahmed * |
| author_sort | Lakhundi, Sahreena |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and 2
protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye 3
susceptible to corneal pathogens. Among bacterial pathogens, the most common agents 4
responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus 5
pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as 6
well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, 7
Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for 8
causing ocular disease. Clinical features include redness, pain, tearing, blur vision and 9
inflammation but symptoms vary depending on the causative agent. The underlying molecular 10
mechanisms associated with microbial pathogenesis include virulence factors as well as the host 11
factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The 12
treatment therefore should focus not only on the elimination of the culprit but also on the 13
neutralization of virulence factors to minimize the damage, in addition to repairing the damaged 14
tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the 15
rational development of therapeutic interventions. This is a timely review of our current 16
understanding of the advances made in this field in a comprehensible manner. Coupled with the 17
recently available genome sequence information and high throughput genomics technology, and 18
the availability of innovative approaches, this will stimulate interest in this field. |
| first_indexed | 2025-11-14T21:13:38Z |
| format | Article |
| id | sunway-465 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:13:38Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-4652019-04-23T01:19:51Z http://eprints.sunway.edu.my/465/ Pathogenesis of microbial keratitis Lakhundi, Sahreena Siddiqui, Ruqaiyyah Bano * Khan, Naveed Ahmed * QR Microbiology Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and 2 protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye 3 susceptible to corneal pathogens. Among bacterial pathogens, the most common agents 4 responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus 5 pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as 6 well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, 7 Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for 8 causing ocular disease. Clinical features include redness, pain, tearing, blur vision and 9 inflammation but symptoms vary depending on the causative agent. The underlying molecular 10 mechanisms associated with microbial pathogenesis include virulence factors as well as the host 11 factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The 12 treatment therefore should focus not only on the elimination of the culprit but also on the 13 neutralization of virulence factors to minimize the damage, in addition to repairing the damaged 14 tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the 15 rational development of therapeutic interventions. This is a timely review of our current 16 understanding of the advances made in this field in a comprehensible manner. Coupled with the 17 recently available genome sequence information and high throughput genomics technology, and 18 the availability of innovative approaches, this will stimulate interest in this field. Elsevier 2016-12-13 Article PeerReviewed text en http://eprints.sunway.edu.my/465/1/zz%20Lakhundi%2BSiddiqui%2BKhan%202016.%20Pathogenesis%20of.pdf Lakhundi, Sahreena and Siddiqui, Ruqaiyyah Bano * and Khan, Naveed Ahmed * (2016) Pathogenesis of microbial keratitis. Microbial Pathogenesis. pp. 1296-1301. ISSN 0882-4010 (In Press) http://www.sciencedirect.com/science/article/pii/S0882401016307586 http://dx.doi.org/10.1016/j.micpath.2016.12.013 |
| spellingShingle | QR Microbiology Lakhundi, Sahreena Siddiqui, Ruqaiyyah Bano * Khan, Naveed Ahmed * Pathogenesis of microbial keratitis |
| title | Pathogenesis of microbial keratitis |
| title_full | Pathogenesis of microbial keratitis |
| title_fullStr | Pathogenesis of microbial keratitis |
| title_full_unstemmed | Pathogenesis of microbial keratitis |
| title_short | Pathogenesis of microbial keratitis |
| title_sort | pathogenesis of microbial keratitis |
| topic | QR Microbiology |
| url | http://eprints.sunway.edu.my/465/ http://eprints.sunway.edu.my/465/ http://eprints.sunway.edu.my/465/ http://eprints.sunway.edu.my/465/1/zz%20Lakhundi%2BSiddiqui%2BKhan%202016.%20Pathogenesis%20of.pdf |