The development of drugs against Acanthamoeba infections
For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively. The discovery of a plethora of antiacanthamoebic compounds has not yielded effective marketed chemotherapeutics. The rate...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2016
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/411/ http://eprints.sunway.edu.my/411/1/proofs.pdf |
| _version_ | 1848801816331943936 |
|---|---|
| author | Siddiqui, Ruqaiyyah Bano * Aqeel, Yousuf Khan, Naveed Ahmed * |
| author_facet | Siddiqui, Ruqaiyyah Bano * Aqeel, Yousuf Khan, Naveed Ahmed * |
| author_sort | Siddiqui, Ruqaiyyah Bano * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively. The discovery of a plethora of antiacanthamoebic compounds has not yielded effective marketed chemotherapeutics. The rate of development of novel antiacanthamoebic chemotherapies of translational
value and the lack of interest of the pharmaceutical industry in developing such chemotherapies have been disappointing. On the other hand, the market for contact lenses/contact lens disinfectants is a multi-billion-dollar industry and has been successful and profitable. A better understanding of drugs, their targets, and mechanisms of action will facilitate the development of more-effective chemotherapies. Here, we review the progress toward phenotypic drug discovery, emphasizing the shortcomings
of useable therapies. |
| first_indexed | 2025-11-14T21:13:28Z |
| format | Article |
| id | sunway-411 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:13:28Z |
| publishDate | 2016 |
| publisher | American Society for Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-4112019-04-23T01:20:08Z http://eprints.sunway.edu.my/411/ The development of drugs against Acanthamoeba infections Siddiqui, Ruqaiyyah Bano * Aqeel, Yousuf Khan, Naveed Ahmed * QR Microbiology For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively. The discovery of a plethora of antiacanthamoebic compounds has not yielded effective marketed chemotherapeutics. The rate of development of novel antiacanthamoebic chemotherapies of translational value and the lack of interest of the pharmaceutical industry in developing such chemotherapies have been disappointing. On the other hand, the market for contact lenses/contact lens disinfectants is a multi-billion-dollar industry and has been successful and profitable. A better understanding of drugs, their targets, and mechanisms of action will facilitate the development of more-effective chemotherapies. Here, we review the progress toward phenotypic drug discovery, emphasizing the shortcomings of useable therapies. American Society for Microbiology 2016-11 Article PeerReviewed text en http://eprints.sunway.edu.my/411/1/proofs.pdf Siddiqui, Ruqaiyyah Bano * and Aqeel, Yousuf and Khan, Naveed Ahmed * (2016) The development of drugs against Acanthamoeba infections. Antimicrobial Agents and Chemotherapy, 60 (11). pp. 6441-6450. ISSN 0066-4804 doi:10.1128/AAC.00686-16. |
| spellingShingle | QR Microbiology Siddiqui, Ruqaiyyah Bano * Aqeel, Yousuf Khan, Naveed Ahmed * The development of drugs against Acanthamoeba infections |
| title | The development of drugs against Acanthamoeba infections |
| title_full | The development of drugs against Acanthamoeba infections |
| title_fullStr | The development of drugs against Acanthamoeba infections |
| title_full_unstemmed | The development of drugs against Acanthamoeba infections |
| title_short | The development of drugs against Acanthamoeba infections |
| title_sort | development of drugs against acanthamoeba infections |
| topic | QR Microbiology |
| url | http://eprints.sunway.edu.my/411/ http://eprints.sunway.edu.my/411/ http://eprints.sunway.edu.my/411/1/proofs.pdf |