A proposed cascade of vascular events leading to granulomatous amoebic encephalitis
Granulomatous amoebic encephalitis due to Acanthamoeba is a chronic disease that almost always results in death. Hematogenous spread is a pre-requisite followed by amoebae invasion of the blood-brain barrier to enter the central nervous system. Given the systemic nature of this infection, a signific...
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| Format: | Article |
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Elsevier
2015
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| Online Access: | http://eprints.sunway.edu.my/313/ |
| _version_ | 1848801798408634368 |
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| author | Baig, Abdul Mannan Khan, Naveed Ahmed * |
| author_facet | Baig, Abdul Mannan Khan, Naveed Ahmed * |
| author_sort | Baig, Abdul Mannan |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Granulomatous amoebic encephalitis due to Acanthamoeba is a chronic disease that almost always results in death. Hematogenous spread is a pre-requisite followed by amoebae invasion of the blood-brain barrier to enter the central nervous system. Given the systemic nature of this infection, a significant latent period of several months before the appearance of clinical manifestations is puzzling. Based on reported cases, here we propose pathogenetic mechanisms that explain the above described latency of the disease. |
| first_indexed | 2025-11-14T21:13:11Z |
| format | Article |
| id | sunway-313 |
| institution | Sunway University |
| institution_category | Local University |
| last_indexed | 2025-11-14T21:13:11Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-3132019-04-23T01:09:31Z http://eprints.sunway.edu.my/313/ A proposed cascade of vascular events leading to granulomatous amoebic encephalitis Baig, Abdul Mannan Khan, Naveed Ahmed * QR Microbiology Granulomatous amoebic encephalitis due to Acanthamoeba is a chronic disease that almost always results in death. Hematogenous spread is a pre-requisite followed by amoebae invasion of the blood-brain barrier to enter the central nervous system. Given the systemic nature of this infection, a significant latent period of several months before the appearance of clinical manifestations is puzzling. Based on reported cases, here we propose pathogenetic mechanisms that explain the above described latency of the disease. Elsevier 2015-11 Article PeerReviewed Baig, Abdul Mannan and Khan, Naveed Ahmed * (2015) A proposed cascade of vascular events leading to granulomatous amoebic encephalitis. Microbial Pathogenesis, 88. pp. 48-51. ISSN 0882-4010 http://www.sciencedirect.com/science/article/pii/S0882401015001308 doi:10.1016/j.micpath.2015.08.005 |
| spellingShingle | QR Microbiology Baig, Abdul Mannan Khan, Naveed Ahmed * A proposed cascade of vascular events leading to granulomatous amoebic encephalitis |
| title | A proposed cascade of vascular events leading to granulomatous amoebic encephalitis |
| title_full | A proposed cascade of vascular events leading to granulomatous amoebic encephalitis |
| title_fullStr | A proposed cascade of vascular events leading to granulomatous amoebic encephalitis |
| title_full_unstemmed | A proposed cascade of vascular events leading to granulomatous amoebic encephalitis |
| title_short | A proposed cascade of vascular events leading to granulomatous amoebic encephalitis |
| title_sort | proposed cascade of vascular events leading to granulomatous amoebic encephalitis |
| topic | QR Microbiology |
| url | http://eprints.sunway.edu.my/313/ http://eprints.sunway.edu.my/313/ http://eprints.sunway.edu.my/313/ |