$In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models$
QR Code

QR Code

In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models

Epilepsy is the third most common known brain disease worldwide. Several antiepileptic drugs (AEDs) are available to improve seizure control. However, the associated side effects limit their practical use and highlight the ongoing search for safer and effective AEDs. Eighteen newly designed fluorine...

Full description

Bibliographic Details
Main Authors:	Muhammad Syafiq, Akmal Mohd Fahmi, Swain, Puspanjali, Amirah, Hani Ramli, Wan Norhamidah, Wan Ibrahim, Nur Atikah, Saleh Hodin, Noraini, Abu Bakar, Tan, Yee Seng *, Siti Munirah, Mohd Faudzi, Kim, Cheol-Hee
Format:	Article
Language:	English
Published:	Elsevier 2023
Subjects:	QD Chemistry
Online Access:	http://eprints.sunway.edu.my/2176/ http://eprints.sunway.edu.my/2176/1/1-s2.0-s2405844023008927-main.pdf

Similar Items

In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models
by: Mohd Fahmi, Muhammad Syafiq Akmal, et al.
Published: (2023)

Synthesis and characterization of pyrrolylated-chalcones as anti methicillin-resistant Staphylococcus aureus agents
by: Gunasekharan, Mohanapriya
Published: (2020)

Zebrafish embryotoxicity and teratogenic effects of Christia vespertilionis leaf extract
by: Norazhar, Anis Irfan, et al.
Published: (2022)

Identification of the anti-epileptic effect of speciogynine through molecular network-aided metabolite profiling of M. speciosa alkaloids using zebrafish
by: Garba, Suleiman Abubakar, et al.
Published: (2025)

Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment
by: Ramli, Amirah Hani, et al.
Published: (2024)

Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones : synthesis, biological activity, crystal structure analysis, and molecular docking studies
by: Siti Munirah, Mohd Faudzi, et al.
Published: (2020)

Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies
by: Mohd Faudzi, Siti Munirah, et al.
Published: (2020)

Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies
by: Mohd Faudzi, Siti Munirah, et al.
Published: (2020)

Mapping molecular networks within Clitoria ternatea Linn. against LPS-induced neuroinflammation in microglial cells, with molecular docking and in vivo toxicity assessment in zebrafish
by: Mat Zian, Nurul Farah Adni, et al.
Published: (2022)

Embryonic mercury exposure in zebrafish: alteration of metabolites and gene expression, related to visual and behavioral impairments
by: Abu Bakar, Noraini, et al.
Published: (2023)

Embryonic arsenic exposure triggers long-term behavioral impairment with metabolite alterations in zebrafish
by: Abu Bakar, Noraini, et al.
Published: (2022)

Molecular cloning and in silico analysis of chalcone isomerase from Polygonum minus
by: Shah, Fatin Lyana Azman, et al.
Published: (2023)

Development and structure activity relationship of diarylpentadienone and chalcone analogues as potential anti-inflammatory agent
by: Mohd Faudzi, Siti Munirah
Published: (2015)

In Silico Study, Synthesis, Characterisation And Cytotoxicity Activity Of New Chalcone, Pyrazoline And Pyrimidine Derivatives
by: Alanazi, Menier Meteb Mohammad
Published: (2021)

From Zebrafish to humans: in silico comparative study of RAD50 sequences
by: Nahid Khalili,, et al.
Published: (2024)

Ethanol induces alteration in swimming activity in zebrafish larvae
by: Ramlan, Nurul Farhana, et al.
Published: (2014)

Developmental exposure to mercury (II) chloride alter behaviour of zebrafish (Danio rerio) larvae
by: Abu Bakar, Noraini, et al.
Published: (2014)

Developmental neurotoxic effects of chronic endosulfan exposure in the zebrafish larvae
by: Ramlan, Nurul F., et al.
Published: (2016)

Oryzias latipes (Japanese medaka) as genetic model to study causative genes of epilepsy disease : an in-silico approach
by: Umi Nabila Mat Yusuf,, et al.
Published: (2022)

Oryzias latipes (JAPANESE MEDAKA) as genetic model to study causative genes of epilepsy disease: an in-silico approach
by: Umi Nabila Mat Yusuf,, et al.
Published: (2022)

Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder
by: Saleh Hodin, Nur Atikah, et al.
Published: (2023)

Fumonisin B1 production by Fusarium species and mycotoxigenic effect on larval zebrafish
by: Azman, Najihah, et al.
Published: (2020)

Chronic embryonic exposure to ethanol induced apoptosis and impairments of behavioral activities in the zebrafish larvae
by: Ramlan, Nurul Farhana, et al.
Published: (2015)

In vitro and in silico insights into the soybean 15-lipoxygenase inhibition with a new C-geranylated chalcone-based flavanone
by: Segaran, Raaginie Tamil, et al.
Published: (2025)

Developmental neurotoxicity assessment of arsenic: evaluation of apoptosis and behavioural response in the zebrafish larvae
by: Abu Bakar, Noraini, et al.
Published: (2015)

Teenagers with epilepsy: a service evaluation of a teenage epilepsy clinic.
by: McRandal, Matthew
Published: (2012)

Exploring sustainability in fluorine methodologies
by: Morgan, Patrick
Published: (2022)

1H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish (Danio rerio) model
by: Chong, Siok Geok, et al.
Published: (2024)

Seizures and epilepsy in pediatric
by: Abd. Aziz, Azian
Published: (2013)

The Flavokawains: Uprising Medicinal Chalcones
by: Akhtar, Muhammad Nadeem, et al.
Published: (2013)

Zebrafish larvae locomotor activity detection using Convolutional NeuraL Network (CNN)
by: Wan Nur Azhani, Wan Samsudin, et al.
Published: (2022)

The flavokawains: uprising medicinal chalcones
by: Abu, Nadiah, et al.
Published: (2013)

Chronic embryonic exposure of arsenic trioxide induced alteration on motor functions and anxiety-like esponses in zebrafish (Danio rerio) larvae
by: Abu Bakar, Noraini, et al.
Published: (2016)

Zebrafish (Danio rerio) vs. Javanese medaka (Oryzias javanicus), who is more anxious?
by: Wan Ibrahim, Wan Norhamidah, et al.
Published: (2016)

Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation
by: Kamal, Rullah, et al.
Published: (2014)

Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: synthesis, biological activity, crystal structure, and in silico evaluation
by: Rullah, Kamal, et al.
Published: (2014)

In silico study and effects of BDMC33 on TNBS-Induced BMP gene expressions in zebrafish gut inflammation-Associated arthritis
by: Mostofa, Farhana, et al.
Published: (2022)

In silico identification of Meyerozyma guilliermondii strain so potential virulence factors and pathogenicity verification of generated mutants in zebrafish model
by: Lim, Si Jie
Published: (2024)

Expression of chalcone synthase and chalcone isomerase from Polygonum minus huds. in Escherichia coli, gene characterization, and structure elucidation of chalcone isomerase
by: Azman Shah, Fatin Lyana
Published: (2020)

Synthesis and Antibacterial Study of Aspirin-Chalcone Derivatives
by: Zainab, Ngaini, et al.
Published: (2013)