Strategies to improve the physicochemical properties of peptide‑based drugs
Peptides are a rapid-growing class of therapeutics with unique and desirable physicochemical properties. Due to disadvantages such as low membrane permeability and susceptibility to proteolytic degradation, peptide-based drugs have limited bioavailability, a short half-life, and rapid in vivo elimin...
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| Format: | Article |
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Springer
2023
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| Online Access: | http://eprints.sunway.edu.my/2159/ |
| _version_ | 1848802213108908032 |
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| author | Lee, Michelle Felicia * Poh, Chit Laa * |
| author_facet | Lee, Michelle Felicia * Poh, Chit Laa * |
| author_sort | Lee, Michelle Felicia * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Peptides are a rapid-growing class of therapeutics with unique and desirable physicochemical properties. Due to disadvantages such as low membrane permeability and susceptibility to proteolytic degradation, peptide-based drugs have limited bioavailability, a short half-life, and rapid in vivo elimination. Various strategies can be applied to improve the physicochemical properties of peptide-based drugs to overcome limitations such as limited tissue residence time, metabolic instability, and low permeability. Applied strategies including backbone modifcations, side chain modifcations, conjugation with polymers, modifcation of peptide termini, fusion to albumin, conjugation with the Fc portion of antibodies, cyclization, stapled peptides, pseudopeptides, cell-penetrating peptide conjugates, conjugation with lipids, and encapsulation in nanocarriers are discussed. |
| first_indexed | 2025-11-14T21:19:46Z |
| format | Article |
| id | sunway-2159 |
| institution | Sunway University |
| institution_category | Local University |
| last_indexed | 2025-11-14T21:19:46Z |
| publishDate | 2023 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-21592023-03-20T03:56:46Z http://eprints.sunway.edu.my/2159/ Strategies to improve the physicochemical properties of peptide‑based drugs Lee, Michelle Felicia * Poh, Chit Laa * RM Therapeutics. Pharmacology Peptides are a rapid-growing class of therapeutics with unique and desirable physicochemical properties. Due to disadvantages such as low membrane permeability and susceptibility to proteolytic degradation, peptide-based drugs have limited bioavailability, a short half-life, and rapid in vivo elimination. Various strategies can be applied to improve the physicochemical properties of peptide-based drugs to overcome limitations such as limited tissue residence time, metabolic instability, and low permeability. Applied strategies including backbone modifcations, side chain modifcations, conjugation with polymers, modifcation of peptide termini, fusion to albumin, conjugation with the Fc portion of antibodies, cyclization, stapled peptides, pseudopeptides, cell-penetrating peptide conjugates, conjugation with lipids, and encapsulation in nanocarriers are discussed. Springer 2023 Article PeerReviewed Lee, Michelle Felicia * and Poh, Chit Laa * (2023) Strategies to improve the physicochemical properties of peptide‑based drugs. Pharmaceutical Research. ISSN 0724-8741 https://link.springer.com/article/10.1007/s11095-023-03486-0 10.1007/s11095-023-03486-0 |
| spellingShingle | RM Therapeutics. Pharmacology Lee, Michelle Felicia * Poh, Chit Laa * Strategies to improve the physicochemical properties of peptide‑based drugs |
| title | Strategies to improve the physicochemical properties of peptide‑based drugs |
| title_full | Strategies to improve the physicochemical properties of peptide‑based drugs |
| title_fullStr | Strategies to improve the physicochemical properties of peptide‑based drugs |
| title_full_unstemmed | Strategies to improve the physicochemical properties of peptide‑based drugs |
| title_short | Strategies to improve the physicochemical properties of peptide‑based drugs |
| title_sort | strategies to improve the physicochemical properties of peptide‑based drugs |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.sunway.edu.my/2159/ http://eprints.sunway.edu.my/2159/ http://eprints.sunway.edu.my/2159/ |