Innate and adaptive immune evasion by dengue virus
Dengue is a mosquito-borne disease which causes significant public health concerns in tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to manipulate the innate immune responses of the host such as ‘hiding’ in the ultrastructure of the host, interfering with the...
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| Format: | Article |
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Frontiers Media
2022
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| Online Access: | http://eprints.sunway.edu.my/2158/ |
| _version_ | 1848802212840472576 |
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| author | Lee, Michelle Felicia * Voon, Guan Zhong * Lim, Hui Xuan * Chua, Mun Lok * Poh, Chit Laa * |
| author_facet | Lee, Michelle Felicia * Voon, Guan Zhong * Lim, Hui Xuan * Chua, Mun Lok * Poh, Chit Laa * |
| author_sort | Lee, Michelle Felicia * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Dengue is a mosquito-borne disease which causes significant public health concerns in tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to manipulate the innate immune responses of the host such as ‘hiding’ in the ultrastructure of the host, interfering with the signaling pathway through RNA modifications, inhibiting type 1 IFN production, as well as inhibiting STAT1 phosphorylation. DENV is also able to evade the adaptive immune responses of the host through antigenic variation, antigendependent enhancement (ADE), partial maturation of prM proteins, and inhibition of antigen presentation. miRNAs are important regulators of both innate and adaptive immunity and they have been shown to play important roles in DENV replication and pathogenesis. This makes them suitable candidates for the development of anti-dengue therapeutics. This review discusses the various strategies employed by DENV to evade innate and adaptive immunity. The role of miRNAs and DENV non-structural proteins (NS) are promising targets for the development of anti-dengue therapeutics. |
| first_indexed | 2025-11-14T21:19:46Z |
| format | Article |
| id | sunway-2158 |
| institution | Sunway University |
| institution_category | Local University |
| last_indexed | 2025-11-14T21:19:46Z |
| publishDate | 2022 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-21582023-03-20T03:34:17Z http://eprints.sunway.edu.my/2158/ Innate and adaptive immune evasion by dengue virus Lee, Michelle Felicia * Voon, Guan Zhong * Lim, Hui Xuan * Chua, Mun Lok * Poh, Chit Laa * RA Public aspects of medicine Dengue is a mosquito-borne disease which causes significant public health concerns in tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to manipulate the innate immune responses of the host such as ‘hiding’ in the ultrastructure of the host, interfering with the signaling pathway through RNA modifications, inhibiting type 1 IFN production, as well as inhibiting STAT1 phosphorylation. DENV is also able to evade the adaptive immune responses of the host through antigenic variation, antigendependent enhancement (ADE), partial maturation of prM proteins, and inhibition of antigen presentation. miRNAs are important regulators of both innate and adaptive immunity and they have been shown to play important roles in DENV replication and pathogenesis. This makes them suitable candidates for the development of anti-dengue therapeutics. This review discusses the various strategies employed by DENV to evade innate and adaptive immunity. The role of miRNAs and DENV non-structural proteins (NS) are promising targets for the development of anti-dengue therapeutics. Frontiers Media 2022-09-16 Article PeerReviewed Lee, Michelle Felicia * and Voon, Guan Zhong * and Lim, Hui Xuan * and Chua, Mun Lok * and Poh, Chit Laa * (2022) Innate and adaptive immune evasion by dengue virus. Frontiers in Cellular and Infection Microbiology, 12. ISSN 2235-2988 https://www.frontiersin.org/articles/10.3389/fcimb.2022.1004608/full 10.3389/fcimb.2022.1004608 |
| spellingShingle | RA Public aspects of medicine Lee, Michelle Felicia * Voon, Guan Zhong * Lim, Hui Xuan * Chua, Mun Lok * Poh, Chit Laa * Innate and adaptive immune evasion by dengue virus |
| title | Innate and adaptive immune evasion by dengue virus |
| title_full | Innate and adaptive immune evasion by dengue virus |
| title_fullStr | Innate and adaptive immune evasion by dengue virus |
| title_full_unstemmed | Innate and adaptive immune evasion by dengue virus |
| title_short | Innate and adaptive immune evasion by dengue virus |
| title_sort | innate and adaptive immune evasion by dengue virus |
| topic | RA Public aspects of medicine |
| url | http://eprints.sunway.edu.my/2158/ http://eprints.sunway.edu.my/2158/ http://eprints.sunway.edu.my/2158/ |