Molecular Mechanisms of Antiviral Agents against Dengue Virus
Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DEN...
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| Format: | Article |
| Language: | English |
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MDPI
2023
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| Online Access: | http://eprints.sunway.edu.my/2156/ http://eprints.sunway.edu.my/2156/1/molecular%20mechanisms%20of%20antiviral%20agents%20against%20dengue%20virus.pdf |
| _version_ | 1848802212262707200 |
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| author | Lee, Michelle Felicia Wu, Yuan Seng Poh, Chit Laa * |
| author_facet | Lee, Michelle Felicia Wu, Yuan Seng Poh, Chit Laa * |
| author_sort | Lee, Michelle Felicia |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics. Various antiviral agents have been developed and investigated for their anti-DENV activities. This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting host receptors and direct-acting antivirals targeting DENV structural and non-structural proteins are reviewed. In addition, the development of antivirals that target different stages during post-infection such as viral replication, viral maturation, and viral assembly are reviewed. Antiviral agents designed based on these molecular mechanisms of action could lead to the discovery and development of novel anti-DENV therapeutics for the treatment of dengue infections. Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection. |
| first_indexed | 2025-11-14T21:19:45Z |
| format | Article |
| id | sunway-2156 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:19:45Z |
| publishDate | 2023 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-21562023-03-20T03:14:17Z http://eprints.sunway.edu.my/2156/ Molecular Mechanisms of Antiviral Agents against Dengue Virus Lee, Michelle Felicia Wu, Yuan Seng Poh, Chit Laa * RA Public aspects of medicine Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics. Various antiviral agents have been developed and investigated for their anti-DENV activities. This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting host receptors and direct-acting antivirals targeting DENV structural and non-structural proteins are reviewed. In addition, the development of antivirals that target different stages during post-infection such as viral replication, viral maturation, and viral assembly are reviewed. Antiviral agents designed based on these molecular mechanisms of action could lead to the discovery and development of novel anti-DENV therapeutics for the treatment of dengue infections. Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection. MDPI 2023-03-08 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/2156/1/molecular%20mechanisms%20of%20antiviral%20agents%20against%20dengue%20virus.pdf Lee, Michelle Felicia and Wu, Yuan Seng and Poh, Chit Laa * (2023) Molecular Mechanisms of Antiviral Agents against Dengue Virus. Viruses, 15 (3). p. 705. ISSN 1999-4915 https://www.mdpi.com/1999-4915/15/3/705 10.3390/v15030705 |
| spellingShingle | RA Public aspects of medicine Lee, Michelle Felicia Wu, Yuan Seng Poh, Chit Laa * Molecular Mechanisms of Antiviral Agents against Dengue Virus |
| title | Molecular Mechanisms of Antiviral Agents against Dengue Virus |
| title_full | Molecular Mechanisms of Antiviral Agents against Dengue Virus |
| title_fullStr | Molecular Mechanisms of Antiviral Agents against Dengue Virus |
| title_full_unstemmed | Molecular Mechanisms of Antiviral Agents against Dengue Virus |
| title_short | Molecular Mechanisms of Antiviral Agents against Dengue Virus |
| title_sort | molecular mechanisms of antiviral agents against dengue virus |
| topic | RA Public aspects of medicine |
| url | http://eprints.sunway.edu.my/2156/ http://eprints.sunway.edu.my/2156/ http://eprints.sunway.edu.my/2156/ http://eprints.sunway.edu.my/2156/1/molecular%20mechanisms%20of%20antiviral%20agents%20against%20dengue%20virus.pdf |