Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update
Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the d...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2021
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| Online Access: | http://eprints.sunway.edu.my/1856/ http://eprints.sunway.edu.my/1856/1/Teow%20Sin%20Yeang%20Development%20of%20a%20polysaccharide-based%20hydrogel%20drug%20delivery%20system%20%28dds%29%20-%20an%20update.pdf |
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| author | Pushpamalar, Janarthanan Puviarasi, M. Tan, Hui Li Nuraina, A. D. Ooi, L. T. Bibi Noorheen, H. M. N. Raahilah, Z. E. Shameli, Kamyar Teow, Sin Yeang * |
| author_facet | Pushpamalar, Janarthanan Puviarasi, M. Tan, Hui Li Nuraina, A. D. Ooi, L. T. Bibi Noorheen, H. M. N. Raahilah, Z. E. Shameli, Kamyar Teow, Sin Yeang * |
| author_sort | Pushpamalar, Janarthanan |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been
extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure
and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of
nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based
materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use. |
| first_indexed | 2025-11-14T21:18:46Z |
| format | Article |
| id | sunway-1856 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:18:46Z |
| publishDate | 2021 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-18562021-10-05T07:32:59Z http://eprints.sunway.edu.my/1856/ Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update Pushpamalar, Janarthanan Puviarasi, M. Tan, Hui Li Nuraina, A. D. Ooi, L. T. Bibi Noorheen, H. M. N. Raahilah, Z. E. Shameli, Kamyar Teow, Sin Yeang * R Medicine (General) Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use. MDPI 2021-09 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1856/1/Teow%20Sin%20Yeang%20Development%20of%20a%20polysaccharide-based%20hydrogel%20drug%20delivery%20system%20%28dds%29%20-%20an%20update.pdf Pushpamalar, Janarthanan and Puviarasi, M. and Tan, Hui Li and Nuraina, A. D. and Ooi, L. T. and Bibi Noorheen, H. M. N. and Raahilah, Z. E. and Shameli, Kamyar and Teow, Sin Yeang * (2021) Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update. Gels, 7 (4). p. 153. ISSN 2310-2861 http://doi.org/10.3390/gels7040153 doi:10.3390/gels7040153 |
| spellingShingle | R Medicine (General) Pushpamalar, Janarthanan Puviarasi, M. Tan, Hui Li Nuraina, A. D. Ooi, L. T. Bibi Noorheen, H. M. N. Raahilah, Z. E. Shameli, Kamyar Teow, Sin Yeang * Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update |
| title | Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update |
| title_full | Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update |
| title_fullStr | Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update |
| title_full_unstemmed | Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update |
| title_short | Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update |
| title_sort | development of a polysaccharide-based hydrogel drug delivery system (dds): an update |
| topic | R Medicine (General) |
| url | http://eprints.sunway.edu.my/1856/ http://eprints.sunway.edu.my/1856/ http://eprints.sunway.edu.my/1856/ http://eprints.sunway.edu.my/1856/1/Teow%20Sin%20Yeang%20Development%20of%20a%20polysaccharide-based%20hydrogel%20drug%20delivery%20system%20%28dds%29%20-%20an%20update.pdf |