Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce...
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| Format: | Article |
| Language: | English |
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Frontiers Media
2021
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| Online Access: | http://eprints.sunway.edu.my/1779/ http://eprints.sunway.edu.my/1779/1/Seyed%20Nano%20and%20Microparticles.pdf |
| _version_ | 1848802132521648128 |
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| author | Jazayeri, S. D. * Lim, Hui Xuan * Shameli, Kamyar Yeap, S. K. Poh, Chit Laa * |
| author_facet | Jazayeri, S. D. * Lim, Hui Xuan * Shameli, Kamyar Yeap, S. K. Poh, Chit Laa * |
| author_sort | Jazayeri, S. D. * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce broad-spectrum and long-lasting immunity. Therefore, to design a successful vaccine, it is essential to stimulate the mucosal as well as systemic immune responses. Successful oral vaccines need to overcome the harsh gastrointestinal environment such as the extremely low pH, proteolytic enzymes, bile salts as well as low permeability and the low immunogenicity of vaccines. In recent years, several delivery systems and adjuvants have been developed for improving oral vaccine delivery and immunogenicity. Formulation of vaccines with nanoparticles and microparticles have been shown to improve antigen stability, availability and adjuvanticity as well as immunostimulatory capacity, target delivery and specific release. This review discusses how nanoparticles (NPs) and microparticles (MPs) as oral carriers with adjuvant characteristics can be beneficial in oral vaccine development. |
| first_indexed | 2025-11-14T21:18:29Z |
| format | Article |
| id | sunway-1779 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:18:29Z |
| publishDate | 2021 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-17792021-08-27T05:36:13Z http://eprints.sunway.edu.my/1779/ Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases Jazayeri, S. D. * Lim, Hui Xuan * Shameli, Kamyar Yeap, S. K. Poh, Chit Laa * QR355 Virology Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce broad-spectrum and long-lasting immunity. Therefore, to design a successful vaccine, it is essential to stimulate the mucosal as well as systemic immune responses. Successful oral vaccines need to overcome the harsh gastrointestinal environment such as the extremely low pH, proteolytic enzymes, bile salts as well as low permeability and the low immunogenicity of vaccines. In recent years, several delivery systems and adjuvants have been developed for improving oral vaccine delivery and immunogenicity. Formulation of vaccines with nanoparticles and microparticles have been shown to improve antigen stability, availability and adjuvanticity as well as immunostimulatory capacity, target delivery and specific release. This review discusses how nanoparticles (NPs) and microparticles (MPs) as oral carriers with adjuvant characteristics can be beneficial in oral vaccine development. Frontiers Media 2021-06 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1779/1/Seyed%20Nano%20and%20Microparticles.pdf Jazayeri, S. D. * and Lim, Hui Xuan * and Shameli, Kamyar and Yeap, S. K. and Poh, Chit Laa * (2021) Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases. Frontiers in Pharmacology, 12. ISSN 1663-9812 http://doi.org/10.3389/fphar.2021.682286 doi:10.3389/fphar.2021.682286 |
| spellingShingle | QR355 Virology Jazayeri, S. D. * Lim, Hui Xuan * Shameli, Kamyar Yeap, S. K. Poh, Chit Laa * Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases |
| title | Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases |
| title_full | Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases |
| title_fullStr | Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases |
| title_full_unstemmed | Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases |
| title_short | Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases |
| title_sort | nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases |
| topic | QR355 Virology |
| url | http://eprints.sunway.edu.my/1779/ http://eprints.sunway.edu.my/1779/ http://eprints.sunway.edu.my/1779/ http://eprints.sunway.edu.my/1779/1/Seyed%20Nano%20and%20Microparticles.pdf |