Development of oncolytic viruses for cancer therapy
Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic viroth...
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| Format: | Article |
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Elsevier
2021
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| Online Access: | http://eprints.sunway.edu.my/1778/ |
| _version_ | 1848802132229095424 |
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| author | Noraini Abd Aziz, * Poh, Chit Laa * |
| author_facet | Noraini Abd Aziz, * Poh, Chit Laa * |
| author_sort | Noraini Abd Aziz, * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic virotherapy has several limitations such as viral delivery to the target, penetration into the tumor mass, and antiviral immune responses. This review provides an insight into the different characteristics of oncolytic viruses (natural and genetically modified) that contribute to effective applications of oncolytic virotherapy in preclinical and clinical trials, and strategies to overcome the limitations. The potential of oncolytic virotherapy combining with other conventional treatments or cancer immunotherapies involving immune checkpoint inhibitors and CAR-T therapy could form part of future multimodality treatment strategies. |
| first_indexed | 2025-11-14T21:18:29Z |
| format | Article |
| id | sunway-1778 |
| institution | Sunway University |
| institution_category | Local University |
| last_indexed | 2025-11-14T21:18:29Z |
| publishDate | 2021 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-17782021-07-14T05:34:16Z http://eprints.sunway.edu.my/1778/ Development of oncolytic viruses for cancer therapy Noraini Abd Aziz, * Poh, Chit Laa * RC0254 Neoplasms. Tumors. Oncology (including Cancer) Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic virotherapy has several limitations such as viral delivery to the target, penetration into the tumor mass, and antiviral immune responses. This review provides an insight into the different characteristics of oncolytic viruses (natural and genetically modified) that contribute to effective applications of oncolytic virotherapy in preclinical and clinical trials, and strategies to overcome the limitations. The potential of oncolytic virotherapy combining with other conventional treatments or cancer immunotherapies involving immune checkpoint inhibitors and CAR-T therapy could form part of future multimodality treatment strategies. Elsevier 2021 Article PeerReviewed Noraini Abd Aziz, * and Poh, Chit Laa * (2021) Development of oncolytic viruses for cancer therapy. Translational Research: The Journal of Laboratory and Clinical Medicine. ISSN 1931-5244 (In Press) http://doi.org/10.1016/j.trsl.2021.04.008 doi:10.1016/j.trsl.2021.04.008 |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Noraini Abd Aziz, * Poh, Chit Laa * Development of oncolytic viruses for cancer therapy |
| title | Development of oncolytic viruses for cancer therapy |
| title_full | Development of oncolytic viruses for cancer therapy |
| title_fullStr | Development of oncolytic viruses for cancer therapy |
| title_full_unstemmed | Development of oncolytic viruses for cancer therapy |
| title_short | Development of oncolytic viruses for cancer therapy |
| title_sort | development of oncolytic viruses for cancer therapy |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/1778/ http://eprints.sunway.edu.my/1778/ http://eprints.sunway.edu.my/1778/ |