Regional diets targeting gut microbial dynamics to support prolonged healthspan
In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to impro...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media
2021
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/1768/ http://eprints.sunway.edu.my/1768/1/Rachel%20Regional%20diets.pdf |
| _version_ | 1848802130193809408 |
|---|---|
| author | Low, Dorrain Yanwen Hejndorf, S. Rachel, Thomas T. * Poppema, Sibrandes * Pettersson, S. |
| author_facet | Low, Dorrain Yanwen Hejndorf, S. Rachel, Thomas T. * Poppema, Sibrandes * Pettersson, S. |
| author_sort | Low, Dorrain Yanwen |
| building | SU Institutional Repository |
| collection | Online Access |
| description | In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to improve healthy ageing for their growing silver generations. As ageing is an inevitable, non-reversing and highly individualised process, we need to better understand how non-genetic factors like diet choices and commensal gut microbes can modulate the biology of ageing. In this review, we discuss how geographical and ethnic variations influence habitual dietary patterns, nutrient structure, and gut microbial profiles with potential impact on the human healthspan. Several gut microbial genera have been associated with healthy elderly populations but are highly variable across populations. It seems unlikely that a universal pro-longevity gut microbiome exists. Rather, the optimal microbiome appears to be conditional on the microbial functionality acting on regional- and ethnicity-specific trends driven by cultural food context. We also highlight dietary and microbial factors that have been observed to elicit individual and clustered biological responses. Finally, we identify next generation avenues to modify otherwise fixed host functions and the individual ageing trajectory by manipulating the malleable gut microbiome with regionally adapted, personalised food intervention regimens targeted at prolonging human healthspan. |
| first_indexed | 2025-11-14T21:18:27Z |
| format | Article |
| id | sunway-1768 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:18:27Z |
| publishDate | 2021 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-17682021-05-28T06:12:37Z http://eprints.sunway.edu.my/1768/ Regional diets targeting gut microbial dynamics to support prolonged healthspan Low, Dorrain Yanwen Hejndorf, S. Rachel, Thomas T. * Poppema, Sibrandes * Pettersson, S. QR Microbiology In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to improve healthy ageing for their growing silver generations. As ageing is an inevitable, non-reversing and highly individualised process, we need to better understand how non-genetic factors like diet choices and commensal gut microbes can modulate the biology of ageing. In this review, we discuss how geographical and ethnic variations influence habitual dietary patterns, nutrient structure, and gut microbial profiles with potential impact on the human healthspan. Several gut microbial genera have been associated with healthy elderly populations but are highly variable across populations. It seems unlikely that a universal pro-longevity gut microbiome exists. Rather, the optimal microbiome appears to be conditional on the microbial functionality acting on regional- and ethnicity-specific trends driven by cultural food context. We also highlight dietary and microbial factors that have been observed to elicit individual and clustered biological responses. Finally, we identify next generation avenues to modify otherwise fixed host functions and the individual ageing trajectory by manipulating the malleable gut microbiome with regionally adapted, personalised food intervention regimens targeted at prolonging human healthspan. Frontiers Media 2021-04 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1768/1/Rachel%20Regional%20diets.pdf Low, Dorrain Yanwen and Hejndorf, S. and Rachel, Thomas T. * and Poppema, Sibrandes * and Pettersson, S. (2021) Regional diets targeting gut microbial dynamics to support prolonged healthspan. Frontiers in Microbiology, 12. ISSN 1664-302X http://doi.org/10.3389/fmicb.2021.659465 doi:10.3389/fmicb.2021.659465 |
| spellingShingle | QR Microbiology Low, Dorrain Yanwen Hejndorf, S. Rachel, Thomas T. * Poppema, Sibrandes * Pettersson, S. Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_full | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_fullStr | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_full_unstemmed | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_short | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_sort | regional diets targeting gut microbial dynamics to support prolonged healthspan |
| topic | QR Microbiology |
| url | http://eprints.sunway.edu.my/1768/ http://eprints.sunway.edu.my/1768/ http://eprints.sunway.edu.my/1768/ http://eprints.sunway.edu.my/1768/1/Rachel%20Regional%20diets.pdf |