Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants
Microbial natural products serve as a good source for antioxidants. The mangrove‐derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley Open
2019
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| Online Access: | http://eprints.sunway.edu.my/1723/ http://eprints.sunway.edu.my/1723/1/Yow%20Yoon%20Yee%20Streptomyces_sp_mum273b_a_mangrove-derived_potenti.pdf |
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| author | Tan, L. T. H. Mahendra, C. K. Yow, Yoon Yen * Chan, Kok Gan Khan, T. M. Lee, L. H. Goh, B. H. |
| author_facet | Tan, L. T. H. Mahendra, C. K. Yow, Yoon Yen * Chan, Kok Gan Khan, T. M. Lee, L. H. Goh, B. H. |
| author_sort | Tan, L. T. H. |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Microbial natural products serve as a good source for antioxidants. The mangrove‐derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV‐protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal‐chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal‐induced lipid peroxidation. Strong correlation
between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB‐induced cell death in HaCaT keratinocytes. Gas chromatography–mass
spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays
an exciting avenue for future antioxidative drugs and cosmeceuticals development. |
| first_indexed | 2025-11-14T21:18:17Z |
| format | Article |
| id | sunway-1723 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:18:17Z |
| publishDate | 2019 |
| publisher | Wiley Open |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-17232021-04-15T01:36:51Z http://eprints.sunway.edu.my/1723/ Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants Tan, L. T. H. Mahendra, C. K. Yow, Yoon Yen * Chan, Kok Gan Khan, T. M. Lee, L. H. Goh, B. H. QH301 Biology Microbial natural products serve as a good source for antioxidants. The mangrove‐derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV‐protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal‐chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal‐induced lipid peroxidation. Strong correlation between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB‐induced cell death in HaCaT keratinocytes. Gas chromatography–mass spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays an exciting avenue for future antioxidative drugs and cosmeceuticals development. Wiley Open 2019 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1723/1/Yow%20Yoon%20Yee%20Streptomyces_sp_mum273b_a_mangrove-derived_potenti.pdf Tan, L. T. H. and Mahendra, C. K. and Yow, Yoon Yen * and Chan, Kok Gan and Khan, T. M. and Lee, L. H. and Goh, B. H. (2019) Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants. MicrobiologyOpen, 8 (10). ISSN 2045-8827 http://doi.org/10.1002/mbo3.859 doi:10.1002/mbo3.859 |
| spellingShingle | QH301 Biology Tan, L. T. H. Mahendra, C. K. Yow, Yoon Yen * Chan, Kok Gan Khan, T. M. Lee, L. H. Goh, B. H. Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title | Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_full | Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_fullStr | Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_full_unstemmed | Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_short | Streptomycessp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_sort | streptomycessp. mum273b: a mangrove‐derived potential source for antioxidant and uvb radiation protectants |
| topic | QH301 Biology |
| url | http://eprints.sunway.edu.my/1723/ http://eprints.sunway.edu.my/1723/ http://eprints.sunway.edu.my/1723/ http://eprints.sunway.edu.my/1723/1/Yow%20Yoon%20Yee%20Streptomyces_sp_mum273b_a_mangrove-derived_potenti.pdf |