Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice
Objective: To evaluate the potential of Gracilaria changii extract in ameliorating the potential adverse effects of bisphenol A. Methods: The antioxidant capacity of Gracilaria changii extracted using different solvents (methanol, ethanol, and aqueous) was studied. The mice were administered by ora...
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Hainan Medical University
2021
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| Online Access: | http://eprints.sunway.edu.my/1693/ http://eprints.sunway.edu.my/1693/1/Yow%20yoon%20yen%20Gracilaria%20changii.pdf |
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| author | Kwong, P. J. Ng, C. L. Tan, G. C. Yow, Yoon Yen * Gupta, M. K. |
| author_facet | Kwong, P. J. Ng, C. L. Tan, G. C. Yow, Yoon Yen * Gupta, M. K. |
| author_sort | Kwong, P. J. |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Objective: To evaluate the potential of Gracilaria changii extract in ameliorating the potential adverse effects of bisphenol A.
Methods: The antioxidant capacity of Gracilaria changii extracted using different solvents (methanol, ethanol, and aqueous) was studied. The mice were administered by oral gavage with bisphenol A (60 mg/kg body weight) for 6 weeks with or without Gracilaria changii aqueous extract. Thereafter, the mice were either euthanized
for histology and immunohistochemistry studies or mated to
evaluate the pregnancy rate.
Results: Gracilaria changii aqueous extract showed the highest antioxidant properties compared with extract using methanol and ethanol. The aqueous extract of Gracilaria changii improved the uterus index and uterine lipid peroxidation after bisphenol A exposure, although the uterine expressions of estrogen receptors and complement C3 were not improved. Histological evaluation of the uterus during the estrus stage has revealed that the extract
could mitigate bisphenol A-induced adverse effects in the uterus as there was a lower percentage of mice showing abnormalities like decreased eosin staining in the myometrium, and decrease in the number of eosinophil and endometrial glands in the endometrium. Besides, Gracilaria changii aqueous extract improved the pregnancy
rate of mice administered with bisphenol A.
Conclusions: Gracilaria changii extract protects against bisphenol A-induced female reproductive abnormalities in mice which may be mediated via modulation of eosinophil migration, endometrial gland formation, and protein expressions associated with prostaglandins in
the myometrium. |
| first_indexed | 2025-11-14T21:18:11Z |
| format | Article |
| id | sunway-1693 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:18:11Z |
| publishDate | 2021 |
| publisher | Hainan Medical University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-16932021-03-22T08:01:11Z http://eprints.sunway.edu.my/1693/ Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice Kwong, P. J. Ng, C. L. Tan, G. C. Yow, Yoon Yen * Gupta, M. K. QH301 Biology Objective: To evaluate the potential of Gracilaria changii extract in ameliorating the potential adverse effects of bisphenol A. Methods: The antioxidant capacity of Gracilaria changii extracted using different solvents (methanol, ethanol, and aqueous) was studied. The mice were administered by oral gavage with bisphenol A (60 mg/kg body weight) for 6 weeks with or without Gracilaria changii aqueous extract. Thereafter, the mice were either euthanized for histology and immunohistochemistry studies or mated to evaluate the pregnancy rate. Results: Gracilaria changii aqueous extract showed the highest antioxidant properties compared with extract using methanol and ethanol. The aqueous extract of Gracilaria changii improved the uterus index and uterine lipid peroxidation after bisphenol A exposure, although the uterine expressions of estrogen receptors and complement C3 were not improved. Histological evaluation of the uterus during the estrus stage has revealed that the extract could mitigate bisphenol A-induced adverse effects in the uterus as there was a lower percentage of mice showing abnormalities like decreased eosin staining in the myometrium, and decrease in the number of eosinophil and endometrial glands in the endometrium. Besides, Gracilaria changii aqueous extract improved the pregnancy rate of mice administered with bisphenol A. Conclusions: Gracilaria changii extract protects against bisphenol A-induced female reproductive abnormalities in mice which may be mediated via modulation of eosinophil migration, endometrial gland formation, and protein expressions associated with prostaglandins in the myometrium. Hainan Medical University 2021-01-05 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/1693/1/Yow%20yoon%20yen%20Gracilaria%20changii.pdf Kwong, P. J. and Ng, C. L. and Tan, G. C. and Yow, Yoon Yen * and Gupta, M. K. (2021) Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice. Asian Pacific Journal of Tropical Medicine, 14 (1). pp. 34-43. ISSN 1995-7645 http://doi.org/10.4103/1995-7645.304299 doi:10.4103/1995-7645.304299 |
| spellingShingle | QH301 Biology Kwong, P. J. Ng, C. L. Tan, G. C. Yow, Yoon Yen * Gupta, M. K. Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
| title | Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
| title_full | Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
| title_fullStr | Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
| title_full_unstemmed | Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
| title_short | Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
| title_sort | gracilaria changii (rhodophyta) alleviates bisphenol a-induced adverse reproductive abnormalities in mice |
| topic | QH301 Biology |
| url | http://eprints.sunway.edu.my/1693/ http://eprints.sunway.edu.my/1693/ http://eprints.sunway.edu.my/1693/ http://eprints.sunway.edu.my/1693/1/Yow%20yoon%20yen%20Gracilaria%20changii.pdf |