Feasibility study of a minibeam collimator design for a 60Co gamma irradiator
Recently much attention has been paid to microbeam and minibeam irradiations, present interest focusing on their use in study of the behaviour of single cells, groups of cells, also their application in spatially fractionated radiotherapy. Synchrotrons are the most common source for microbeam radiot...
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Elsevier
2021
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| Online Access: | http://eprints.sunway.edu.my/1570/ |
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| author | Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. * |
| author_facet | Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. * |
| author_sort | Moradi, F. |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Recently much attention has been paid to microbeam and minibeam irradiations, present interest focusing on their use in study of the behaviour of single cells, groups of cells, also their application in spatially fractionated radiotherapy. Synchrotrons are the most common source for microbeam radiotherapy (MRT), albeit limited in access and typically offering photon energies very much lower than familiar in the practice of conventional radiotherapy. In this study of feasibility, the design has been investigated of a collimator coupled to a conventional 60Co gamma-irradiator sample chamber to produce a minibeam. MCNPX code Monte Carlo simulations were used to model a Gammacell 220 60Co irradiator with lead and tungsten collimators. The dose profile was evaluated in the absence and presence of the collimator, seeking to optimize collimator design. The results pertain to specific shapes of lead and tungsten collimators producing narrow (millimeter dimension) beams, sufficient in thickness but yet still fitting within the sample chamber, with a peak-to-valley dose ratio (PVDR) greater than 15. The beam size can be tailored with modification in the size of the perforated part, the collimator optimized to minimize the dose-rate at points away from the collimator centre. However the dose-rate at the centre is reduced to between 2 to 20% of that in the absence of collimator. The findings of this study encourage the development of minibeam collimator for gamma irradiators, useful for preclinical minibeam radiotherapy research in centres with little or no access to other appropriate sources. |
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| format | Article |
| id | sunway-1570 |
| institution | Sunway University |
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| last_indexed | 2025-11-14T21:17:48Z |
| publishDate | 2021 |
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| spelling | sunway-15702021-11-18T01:53:33Z http://eprints.sunway.edu.my/1570/ Feasibility study of a minibeam collimator design for a 60Co gamma irradiator Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. * R895-920 Medical Physics/Medical Radiology Recently much attention has been paid to microbeam and minibeam irradiations, present interest focusing on their use in study of the behaviour of single cells, groups of cells, also their application in spatially fractionated radiotherapy. Synchrotrons are the most common source for microbeam radiotherapy (MRT), albeit limited in access and typically offering photon energies very much lower than familiar in the practice of conventional radiotherapy. In this study of feasibility, the design has been investigated of a collimator coupled to a conventional 60Co gamma-irradiator sample chamber to produce a minibeam. MCNPX code Monte Carlo simulations were used to model a Gammacell 220 60Co irradiator with lead and tungsten collimators. The dose profile was evaluated in the absence and presence of the collimator, seeking to optimize collimator design. The results pertain to specific shapes of lead and tungsten collimators producing narrow (millimeter dimension) beams, sufficient in thickness but yet still fitting within the sample chamber, with a peak-to-valley dose ratio (PVDR) greater than 15. The beam size can be tailored with modification in the size of the perforated part, the collimator optimized to minimize the dose-rate at points away from the collimator centre. However the dose-rate at the centre is reduced to between 2 to 20% of that in the absence of collimator. The findings of this study encourage the development of minibeam collimator for gamma irradiators, useful for preclinical minibeam radiotherapy research in centres with little or no access to other appropriate sources. Elsevier 2021-06-11 Article PeerReviewed Moradi, F. and Khandaker, Mayeen Uddin * and Abdul Sani, S.F. and Uguru, E.H. and Sulieman, A. and Bradley, D.A. * (2021) Feasibility study of a minibeam collimator design for a 60Co gamma irradiator. Radiation Physics and Chemistry, 178. p. 109026. ISSN 0969806X http://doi.org/10.1016/j.radphyschem.2020.109026 doi:10.1016/j.radphyschem.2020.109026 |
| spellingShingle | R895-920 Medical Physics/Medical Radiology Moradi, F. Khandaker, Mayeen Uddin * Abdul Sani, S.F. Uguru, E.H. Sulieman, A. Bradley, D.A. * Feasibility study of a minibeam collimator design for a 60Co gamma irradiator |
| title | Feasibility study of a minibeam collimator design for a 60Co gamma irradiator |
| title_full | Feasibility study of a minibeam collimator design for a 60Co gamma irradiator |
| title_fullStr | Feasibility study of a minibeam collimator design for a 60Co gamma irradiator |
| title_full_unstemmed | Feasibility study of a minibeam collimator design for a 60Co gamma irradiator |
| title_short | Feasibility study of a minibeam collimator design for a 60Co gamma irradiator |
| title_sort | feasibility study of a minibeam collimator design for a 60co gamma irradiator |
| topic | R895-920 Medical Physics/Medical Radiology |
| url | http://eprints.sunway.edu.my/1570/ http://eprints.sunway.edu.my/1570/ http://eprints.sunway.edu.my/1570/ |