High expression of LC3A, LC3B, and p62/SQSTM1 autophagic proteins in human colonic ganglion cells
Introduction: Autophagy is a mechanism that degrades large damaged organelles and misfolded proteins to maintain the homeostasis in all cells. It plays double-faceted roles in tumourigenesis and prevention of various cancers. In our side observation of investigating the prognostic value of autophag...
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College of Pathologists, Academy of Medicine Malaysia
2020
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| Online Access: | http://eprints.sunway.edu.my/1564/ http://eprints.sunway.edu.my/1564/1/Teow%20Sin%20Yeang%20High%20Expression%20of%20LC3A%20LC3B%20and%20p62_SQSTM1%20Autophagic%20Proteins%20in%20Human%20Colonic%20Ganglion%20Cells.pdf |
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| author | Awi, Noel Jacques * Armon, Subasri Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * |
| author_facet | Awi, Noel Jacques * Armon, Subasri Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * |
| author_sort | Awi, Noel Jacques * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Introduction: Autophagy is a mechanism that degrades large damaged organelles and misfolded proteins to maintain the homeostasis in all cells. It plays double-faceted roles in tumourigenesis and prevention of various cancers. In our side observation of investigating the prognostic value of
autophagy in colorectal cancer (CRC), we found high expression of autophagy proteins (LC3A, LC3B, and p62/SQSTM1) in the colonic ganglion cells. To our best understanding, this is the first paper reporting such finding. Materials and Methods: Formalin-fixed paraffin-embedded (FFPE) CRC tissues blocks were retrieved and confirmed by haematoxylin & eosin (H&E) staining.
Immunohistochemistry (IHC) targeting autophagy proteins (LC3A, LC3B, and p62/SQSTM1) was then performed followed by pathological examination. Results: All three autophagy proteins were present in both normal and tumour tissues of CRC patients. Interestingly, high expression of autophagy proteins in colonic ganglion cells was consistently seen regardless of tissue type (normal or cancer) or tumour site (caecum, ascending, transverse, descending, sigmoid colon and rectum). Conclusions: This work highlights the high autophagic activities in human colonic ganglion cells. |
| first_indexed | 2025-11-14T21:17:47Z |
| format | Article |
| id | sunway-1564 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:17:47Z |
| publishDate | 2020 |
| publisher | College of Pathologists, Academy of Medicine Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-15642021-01-27T06:10:03Z http://eprints.sunway.edu.my/1564/ High expression of LC3A, LC3B, and p62/SQSTM1 autophagic proteins in human colonic ganglion cells Awi, Noel Jacques * Armon, Subasri Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * RC0254 Neoplasms. Tumors. Oncology (including Cancer) Introduction: Autophagy is a mechanism that degrades large damaged organelles and misfolded proteins to maintain the homeostasis in all cells. It plays double-faceted roles in tumourigenesis and prevention of various cancers. In our side observation of investigating the prognostic value of autophagy in colorectal cancer (CRC), we found high expression of autophagy proteins (LC3A, LC3B, and p62/SQSTM1) in the colonic ganglion cells. To our best understanding, this is the first paper reporting such finding. Materials and Methods: Formalin-fixed paraffin-embedded (FFPE) CRC tissues blocks were retrieved and confirmed by haematoxylin & eosin (H&E) staining. Immunohistochemistry (IHC) targeting autophagy proteins (LC3A, LC3B, and p62/SQSTM1) was then performed followed by pathological examination. Results: All three autophagy proteins were present in both normal and tumour tissues of CRC patients. Interestingly, high expression of autophagy proteins in colonic ganglion cells was consistently seen regardless of tissue type (normal or cancer) or tumour site (caecum, ascending, transverse, descending, sigmoid colon and rectum). Conclusions: This work highlights the high autophagic activities in human colonic ganglion cells. College of Pathologists, Academy of Medicine Malaysia 2020-04 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1564/1/Teow%20Sin%20Yeang%20High%20Expression%20of%20LC3A%20LC3B%20and%20p62_SQSTM1%20Autophagic%20Proteins%20in%20Human%20Colonic%20Ganglion%20Cells.pdf Awi, Noel Jacques * and Armon, Subasri and Peh, Kaik-Boo and Peh, Suat Cheng * and Teow, Sin Yeang * (2020) High expression of LC3A, LC3B, and p62/SQSTM1 autophagic proteins in human colonic ganglion cells. Malaysian Journal of Pathology, 42 (1). pp. 85-90. ISSN 0126 8635 http://www.mjpath.org.my/about-mjpath.php |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Awi, Noel Jacques * Armon, Subasri Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * High expression of LC3A, LC3B, and p62/SQSTM1 autophagic proteins in human colonic ganglion cells |
| title | High expression of LC3A, LC3B, and p62/SQSTM1 autophagic
proteins in human colonic ganglion cells |
| title_full | High expression of LC3A, LC3B, and p62/SQSTM1 autophagic
proteins in human colonic ganglion cells |
| title_fullStr | High expression of LC3A, LC3B, and p62/SQSTM1 autophagic
proteins in human colonic ganglion cells |
| title_full_unstemmed | High expression of LC3A, LC3B, and p62/SQSTM1 autophagic
proteins in human colonic ganglion cells |
| title_short | High expression of LC3A, LC3B, and p62/SQSTM1 autophagic
proteins in human colonic ganglion cells |
| title_sort | high expression of lc3a, lc3b, and p62/sqstm1 autophagic
proteins in human colonic ganglion cells |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/1564/ http://eprints.sunway.edu.my/1564/ http://eprints.sunway.edu.my/1564/1/Teow%20Sin%20Yeang%20High%20Expression%20of%20LC3A%20LC3B%20and%20p62_SQSTM1%20Autophagic%20Proteins%20in%20Human%20Colonic%20Ganglion%20Cells.pdf |