Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients.
Prostate cancer is one of the most common cancers affecting men. Bone scan is part of the staging modality commonly used to evaluate bone metastasis. A bone scan with diffused increased skeletal tracer uptake relative to soft tissue, combined with faint renal activity is known as a superscan. Howe...
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Elsevier
2021
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| Online Access: | http://eprints.sunway.edu.my/1541/ http://eprints.sunway.edu.my/1541/1/Chew%20Ming%20Tsuey%20Superscan-superiority%20of%20xSPECT-CT%20over%20OSEM%20SPECT-CT%20in%20bone%20scans%20of%20prostate%20cancer%20patients%20%28003%29.pdf |
| _version_ | 1848802081931001856 |
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| author | Chen, Ew-Jun * Tan, Teik Hin * Chew, Ming Tsuey * |
| author_facet | Chen, Ew-Jun * Tan, Teik Hin * Chew, Ming Tsuey * |
| author_sort | Chen, Ew-Jun * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Prostate cancer is one of the most common cancers affecting men. Bone scan is part of the staging modality
commonly used to evaluate bone metastasis. A bone scan with diffused increased skeletal tracer uptake relative
to soft tissue, combined with faint renal activity is known as a superscan. However, a primary concern are false
negatives associated with bone scans, where diffuse metastasis is indistinguishable on superscans. In this study, we performed xSPECT/CT Bone and standard OSEM SPECT/CT reconstruction algorithm in ten prostate cancer
patients with high PSA levels, where they initially seem relatively unremarkable on planar images. All patients
with extensive bone metastases showed either relatively unremarkable scans or did not demonstrate the true
extent of metastatic burden as seen on planar images. Uptake was further confirmed by the correlative diffuse
bone lesions on CT images. Our reports also indicated that xSPECT/CT reconstructed images were far superior in
delineating focal areas of osteoblastic bone metastasis, when compared with whole body planar images or
SPECT/CT images. The extent of metastatic evidence is delineated with excellent clarification by xSPECT/CT
images. We propose that whole body xSPECT/CT image reconstruction, or at least SPECT/CT, should be performed in patients with high PSA levels, along with planar imaging, to improve diagnostic accuracy of bone
scans in prostate cancer staging. |
| first_indexed | 2025-11-14T21:17:41Z |
| format | Article |
| id | sunway-1541 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:17:41Z |
| publishDate | 2021 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-15412020-12-14T04:08:37Z http://eprints.sunway.edu.my/1541/ Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. Chen, Ew-Jun * Tan, Teik Hin * Chew, Ming Tsuey * R895-920 Medical Physics/Medical Radiology RC0254 Neoplasms. Tumors. Oncology (including Cancer) Prostate cancer is one of the most common cancers affecting men. Bone scan is part of the staging modality commonly used to evaluate bone metastasis. A bone scan with diffused increased skeletal tracer uptake relative to soft tissue, combined with faint renal activity is known as a superscan. However, a primary concern are false negatives associated with bone scans, where diffuse metastasis is indistinguishable on superscans. In this study, we performed xSPECT/CT Bone and standard OSEM SPECT/CT reconstruction algorithm in ten prostate cancer patients with high PSA levels, where they initially seem relatively unremarkable on planar images. All patients with extensive bone metastases showed either relatively unremarkable scans or did not demonstrate the true extent of metastatic burden as seen on planar images. Uptake was further confirmed by the correlative diffuse bone lesions on CT images. Our reports also indicated that xSPECT/CT reconstructed images were far superior in delineating focal areas of osteoblastic bone metastasis, when compared with whole body planar images or SPECT/CT images. The extent of metastatic evidence is delineated with excellent clarification by xSPECT/CT images. We propose that whole body xSPECT/CT image reconstruction, or at least SPECT/CT, should be performed in patients with high PSA levels, along with planar imaging, to improve diagnostic accuracy of bone scans in prostate cancer staging. Elsevier 2021-05-12 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1541/1/Chew%20Ming%20Tsuey%20Superscan-superiority%20of%20xSPECT-CT%20over%20OSEM%20SPECT-CT%20in%20bone%20scans%20of%20prostate%20cancer%20patients%20%28003%29.pdf Chen, Ew-Jun * and Tan, Teik Hin * and Chew, Ming Tsuey * (2021) Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. Radiation Physics and Chemistry, 178. p. 108998. ISSN 0969806X http://doi.org/10.1016/j.radphyschem.2020.108998 doi:10.1016/j.radphyschem.2020.108998 |
| spellingShingle | R895-920 Medical Physics/Medical Radiology RC0254 Neoplasms. Tumors. Oncology (including Cancer) Chen, Ew-Jun * Tan, Teik Hin * Chew, Ming Tsuey * Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. |
| title | Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. |
| title_full | Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. |
| title_fullStr | Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. |
| title_full_unstemmed | Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. |
| title_short | Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients. |
| title_sort | superscan: superiority of xspect/ct over osem spect/ct in bone scans of prostate cancer patients. |
| topic | R895-920 Medical Physics/Medical Radiology RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/1541/ http://eprints.sunway.edu.my/1541/ http://eprints.sunway.edu.my/1541/ http://eprints.sunway.edu.my/1541/1/Chew%20Ming%20Tsuey%20Superscan-superiority%20of%20xSPECT-CT%20over%20OSEM%20SPECT-CT%20in%20bone%20scans%20of%20prostate%20cancer%20patients%20%28003%29.pdf |