Colon Carcinogenesis: The interplay between diet and gut microbiota
Colorectal cancer (CRC) incidence increases yearly, and is three to four times higher in developed countries compared to developing countries. The well-known risk factors have been attributed to low physical activity, overweight, obesity, dietary consumption including excessive consumption of red pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media
2020
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| Online Access: | http://eprints.sunway.edu.my/1539/ http://eprints.sunway.edu.my/1539/1/Ming%20Tsuey%20Colon%20carcinogenesis-the%20interplay%20between%20diet%20and%20gut%20microbiota.pdf |
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| author | Loke, Yean Leng Chew, Ming Tsuey * Ngeow, Yun Fong Lim, Wendy Wan Dee Peh, Suat Cheng * |
| author_facet | Loke, Yean Leng Chew, Ming Tsuey * Ngeow, Yun Fong Lim, Wendy Wan Dee Peh, Suat Cheng * |
| author_sort | Loke, Yean Leng |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Colorectal cancer (CRC) incidence increases yearly, and is three to four times higher in developed countries compared to developing countries. The well-known risk factors have been attributed to low physical activity, overweight, obesity, dietary consumption including excessive consumption of red processed meats, alcohol, and low dietary fiber content. There is growing evidence of the interplay between diet and gut microbiota in CRC carcinogenesis. Although there appears to be a direct causal role for gut microbes in the development of CRC in some animal models, the link between diet, gut microbes, and colonic carcinogenesis has been established largely as an association rather than as a cause-and-effect relationship. This is especially true for human studies. As essential dietary factors influence CRC risk, the role of proteins, carbohydrates, fat, and their end products are considered as part of the interplay between diet and gut microbiota. The underlying molecular mechanisms of colon carcinogenesis mediated by gut microbiota are also discussed. Human biological responses such as inflammation, oxidative stress, deoxyribonucleic acid (DNA) damage can all influence dysbiosis and consequently CRC carcinogenesis. Dysbiosis could add to CRC risk by shifting the effect of dietary components toward promoting a colonic neoplasm together with interacting with gut microbiota. It follows that dietary intervention and gut microbiota modulation may play a vital role in reducing CRC risk. |
| first_indexed | 2025-11-14T21:17:41Z |
| format | Article |
| id | sunway-1539 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:17:41Z |
| publishDate | 2020 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-15392020-12-08T05:59:58Z http://eprints.sunway.edu.my/1539/ Colon Carcinogenesis: The interplay between diet and gut microbiota Loke, Yean Leng Chew, Ming Tsuey * Ngeow, Yun Fong Lim, Wendy Wan Dee Peh, Suat Cheng * RC0254 Neoplasms. Tumors. Oncology (including Cancer) Colorectal cancer (CRC) incidence increases yearly, and is three to four times higher in developed countries compared to developing countries. The well-known risk factors have been attributed to low physical activity, overweight, obesity, dietary consumption including excessive consumption of red processed meats, alcohol, and low dietary fiber content. There is growing evidence of the interplay between diet and gut microbiota in CRC carcinogenesis. Although there appears to be a direct causal role for gut microbes in the development of CRC in some animal models, the link between diet, gut microbes, and colonic carcinogenesis has been established largely as an association rather than as a cause-and-effect relationship. This is especially true for human studies. As essential dietary factors influence CRC risk, the role of proteins, carbohydrates, fat, and their end products are considered as part of the interplay between diet and gut microbiota. The underlying molecular mechanisms of colon carcinogenesis mediated by gut microbiota are also discussed. Human biological responses such as inflammation, oxidative stress, deoxyribonucleic acid (DNA) damage can all influence dysbiosis and consequently CRC carcinogenesis. Dysbiosis could add to CRC risk by shifting the effect of dietary components toward promoting a colonic neoplasm together with interacting with gut microbiota. It follows that dietary intervention and gut microbiota modulation may play a vital role in reducing CRC risk. Frontiers Media 2020-12-08 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1539/1/Ming%20Tsuey%20Colon%20carcinogenesis-the%20interplay%20between%20diet%20and%20gut%20microbiota.pdf Loke, Yean Leng and Chew, Ming Tsuey * and Ngeow, Yun Fong and Lim, Wendy Wan Dee and Peh, Suat Cheng * (2020) Colon Carcinogenesis: The interplay between diet and gut microbiota. Frontiers in Cellular and Infection Microbiology, 10. ISSN 2235-2988 |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Loke, Yean Leng Chew, Ming Tsuey * Ngeow, Yun Fong Lim, Wendy Wan Dee Peh, Suat Cheng * Colon Carcinogenesis: The interplay between diet and gut microbiota |
| title | Colon Carcinogenesis: The interplay between diet and gut microbiota |
| title_full | Colon Carcinogenesis: The interplay between diet and gut microbiota |
| title_fullStr | Colon Carcinogenesis: The interplay between diet and gut microbiota |
| title_full_unstemmed | Colon Carcinogenesis: The interplay between diet and gut microbiota |
| title_short | Colon Carcinogenesis: The interplay between diet and gut microbiota |
| title_sort | colon carcinogenesis: the interplay between diet and gut microbiota |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/1539/ http://eprints.sunway.edu.my/1539/1/Ming%20Tsuey%20Colon%20carcinogenesis-the%20interplay%20between%20diet%20and%20gut%20microbiota.pdf |