Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers
There has been a great interest in myeloid-derived suppressor cells (MDSCs) due to their biological functions in tumor-mediated immune escape by suppressing antitumor immune responses. These cells arise from altered myelopoiesis in response to the tumor-derived factors. The most recognized function...
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| Format: | Article |
| Language: | English |
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MDPI
2020
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| Online Access: | http://eprints.sunway.edu.my/1300/ http://eprints.sunway.edu.my/1300/1/Malihe%20Understanding%20the%20Differentiation%20Expansion.pdf |
| _version_ | 1848802021947211776 |
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| author | Lim, Hui Xuan * Kim, Tae Sung Poh, Chit Laa * |
| author_facet | Lim, Hui Xuan * Kim, Tae Sung Poh, Chit Laa * |
| author_sort | Lim, Hui Xuan * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | There has been a great interest in myeloid-derived suppressor cells (MDSCs) due to their biological functions in tumor-mediated immune escape by suppressing antitumor immune responses. These cells arise from altered myelopoiesis in response to the tumor-derived factors. The most recognized function of MDSCs is suppressing anti-tumor immune responses by impairing T cell functions, and these cells are the most important players in cancer dissemination and metastasis. Therefore, understanding the factors and the mechanism of MDSC differentiation, expansion, and recruitment into the tumor microenvironment can lead to its control. However, most of the studies only defined MDSCs with no further characterization of granulocytic and monocytic subsets. In this review, we discuss the mechanisms by which specific MDSC subsets contribute to cancers. A better understanding of MDSC subset development and the specific molecular mechanism is needed to identify treatment targets. The understanding of the specific molecular mechanisms responsible for MDSC accumulation would enable more precise therapeutic targeting of these cells. |
| first_indexed | 2025-11-14T21:16:44Z |
| format | Article |
| id | sunway-1300 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:16:44Z |
| publishDate | 2020 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-13002020-06-03T03:06:04Z http://eprints.sunway.edu.my/1300/ Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers Lim, Hui Xuan * Kim, Tae Sung Poh, Chit Laa * QR355 Virology There has been a great interest in myeloid-derived suppressor cells (MDSCs) due to their biological functions in tumor-mediated immune escape by suppressing antitumor immune responses. These cells arise from altered myelopoiesis in response to the tumor-derived factors. The most recognized function of MDSCs is suppressing anti-tumor immune responses by impairing T cell functions, and these cells are the most important players in cancer dissemination and metastasis. Therefore, understanding the factors and the mechanism of MDSC differentiation, expansion, and recruitment into the tumor microenvironment can lead to its control. However, most of the studies only defined MDSCs with no further characterization of granulocytic and monocytic subsets. In this review, we discuss the mechanisms by which specific MDSC subsets contribute to cancers. A better understanding of MDSC subset development and the specific molecular mechanism is needed to identify treatment targets. The understanding of the specific molecular mechanisms responsible for MDSC accumulation would enable more precise therapeutic targeting of these cells. MDPI 2020-05-20 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1300/1/Malihe%20Understanding%20the%20Differentiation%20Expansion.pdf Lim, Hui Xuan * and Kim, Tae Sung and Poh, Chit Laa * (2020) Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers. International Journal of Molecular Sciences, 21 (10). p. 3599. ISSN 1422-0067 http://doi.org/10.3390/ijms21103599 doi:10.3390/ijms21103599 |
| spellingShingle | QR355 Virology Lim, Hui Xuan * Kim, Tae Sung Poh, Chit Laa * Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers |
| title | Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers |
| title_full | Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers |
| title_fullStr | Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers |
| title_full_unstemmed | Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers |
| title_short | Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers |
| title_sort | understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers |
| topic | QR355 Virology |
| url | http://eprints.sunway.edu.my/1300/ http://eprints.sunway.edu.my/1300/ http://eprints.sunway.edu.my/1300/ http://eprints.sunway.edu.my/1300/1/Malihe%20Understanding%20the%20Differentiation%20Expansion.pdf |