Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands
Four new mixed ligand dioxidomolybdenum(VI) [MoVIO2L1-3(Q)] (1–3), [MoVIO2L4(Q)]2 (H2O) (4) [where Q = MeOH for 1 and imidazole for 2–4] complexes have been synthesized using four different ONO donor aroylhydrazone ligands (H2L1–4). All the derived ligands and complexes have been characterised by di...
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| Format: | Article |
| Language: | English |
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Elsevier
2020
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| Online Access: | http://eprints.sunway.edu.my/1276/ http://eprints.sunway.edu.my/1276/1/Tiekink%20Investigation%20of%20DNA.pdf |
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| author | Dinda, Rupam Panda, Arpita Banerjee, Atanu Mohanty, Monalisa Pasayat, Sagarika Tiekink, Edward R. T. * |
| author_facet | Dinda, Rupam Panda, Arpita Banerjee, Atanu Mohanty, Monalisa Pasayat, Sagarika Tiekink, Edward R. T. * |
| author_sort | Dinda, Rupam |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Four new mixed ligand dioxidomolybdenum(VI) [MoVIO2L1-3(Q)] (1–3), [MoVIO2L4(Q)]2 (H2O) (4) [where Q = MeOH for 1 and imidazole for 2–4] complexes have been synthesized using four different ONO donor aroylhydrazone ligands (H2L1–4). All the derived ligands and complexes have been characterised by different physicochemical techniques, that is, elemental analysis, spectroscopic methods (UV–Vis, NMR and IR), and cyclic voltammetry. The molecular geometries of 1–4 were established by X-ray crystallography which reveals - - the Schiff base ligands coordinate - the distorted octahedral metal centres in a di-negative tridentate fashion. The complexes have shown moderate binding affinity (103 to 104 M−1) towards CT-DNA. Further, in vitro cytotoxicity activity of all the complexes were determined against HT-29 (colon cancer) and HeLa (cervical cancer) cell lines. Complex 4, due to the presence of a heterocyclic 2-hydroxy-1-naphthyl moiety in the ligand backbone, was found to be more biologically active in comparison to the others in the series. |
| first_indexed | 2025-11-14T21:16:38Z |
| format | Article |
| id | sunway-1276 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:16:38Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-12762020-10-07T07:44:39Z http://eprints.sunway.edu.my/1276/ Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands Dinda, Rupam Panda, Arpita Banerjee, Atanu Mohanty, Monalisa Pasayat, Sagarika Tiekink, Edward R. T. * QD Chemistry Four new mixed ligand dioxidomolybdenum(VI) [MoVIO2L1-3(Q)] (1–3), [MoVIO2L4(Q)]2 (H2O) (4) [where Q = MeOH for 1 and imidazole for 2–4] complexes have been synthesized using four different ONO donor aroylhydrazone ligands (H2L1–4). All the derived ligands and complexes have been characterised by different physicochemical techniques, that is, elemental analysis, spectroscopic methods (UV–Vis, NMR and IR), and cyclic voltammetry. The molecular geometries of 1–4 were established by X-ray crystallography which reveals - - the Schiff base ligands coordinate - the distorted octahedral metal centres in a di-negative tridentate fashion. The complexes have shown moderate binding affinity (103 to 104 M−1) towards CT-DNA. Further, in vitro cytotoxicity activity of all the complexes were determined against HT-29 (colon cancer) and HeLa (cervical cancer) cell lines. Complex 4, due to the presence of a heterocyclic 2-hydroxy-1-naphthyl moiety in the ligand backbone, was found to be more biologically active in comparison to the others in the series. Elsevier 2020-03-30 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1276/1/Tiekink%20Investigation%20of%20DNA.pdf Dinda, Rupam and Panda, Arpita and Banerjee, Atanu and Mohanty, Monalisa and Pasayat, Sagarika and Tiekink, Edward R. T. * (2020) Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands. Polyhedron, 183. p. 114533. ISSN 02775387 (In Press) http://doi.org/10.1016/j.poly.2020.114533 doi:10.1016/j.poly.2020.114533 |
| spellingShingle | QD Chemistry Dinda, Rupam Panda, Arpita Banerjee, Atanu Mohanty, Monalisa Pasayat, Sagarika Tiekink, Edward R. T. * Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands |
| title | Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands |
| title_full | Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands |
| title_fullStr | Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands |
| title_full_unstemmed | Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands |
| title_short | Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands |
| title_sort | investigation of dna interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(vi) complexes incorporating ono donor aroylhydrazone ligands |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/1276/ http://eprints.sunway.edu.my/1276/ http://eprints.sunway.edu.my/1276/ http://eprints.sunway.edu.my/1276/1/Tiekink%20Investigation%20of%20DNA.pdf |