Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC)
Colorectal cancer (CRC) continues to be one of the most common cancers globally. The incidence has increased in developing countries in the past few decades, this could be partly attributed to aging populations and unhealthy lifestyles. While the treatment of CRC has seen significant improvement sin...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2019
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| Online Access: | http://eprints.sunway.edu.my/1198/ http://eprints.sunway.edu.my/1198/1/Teow%20Sin%20Yeang%20Current%20update%20of%20laboratory%20molecular%20diagnostics%20advancesment%20in%20management%20of%20colorectal%20cancer%20%28CRC%29.pdf |
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| author | Pang, Siew Wai * Awi, Noel Jacques * Armon, Subasri Lim, Wendy Wan-Dee Low, John Seng-Hooi Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * |
| author_facet | Pang, Siew Wai * Awi, Noel Jacques * Armon, Subasri Lim, Wendy Wan-Dee Low, John Seng-Hooi Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * |
| author_sort | Pang, Siew Wai * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Colorectal cancer (CRC) continues to be one of the most common cancers globally. The incidence has increased in developing countries in the past few decades, this could be partly attributed to aging populations and unhealthy lifestyles. While the treatment of CRC has seen significant improvement since the advent of target-specific therapies and personalized medicine, CRC is oftentimes detected at late or advanced stages, thereby reducing the efficacy of treatment. Hence, screening for early detection is still the key to combat CRC and to increase overall survival (OS). Considering that the field of medical diagnostics is moving towards molecular diagnostics, CRC can now be effectively screened and diagnosed with high accuracy and sensitivity. Depending on the tumor genotype and genetic profile of the individual, personalized treatments including tyrosine kinase inhibitor therapy and immunotherapy can be administered. Notably, there can be no one single treatment that is effective for all CRC patients due to the variation in tumor genetics, which highlights the importance of molecular diagnostics. This review provides insights on therapeutic modalities, molecular biomarkers, advancement of diagnostic technologies, and current challenges in managing CRC. |
| first_indexed | 2025-11-14T21:16:20Z |
| format | Article |
| id | sunway-1198 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:16:20Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-11982019-12-31T01:59:15Z http://eprints.sunway.edu.my/1198/ Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC) Pang, Siew Wai * Awi, Noel Jacques * Armon, Subasri Lim, Wendy Wan-Dee Low, John Seng-Hooi Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology Colorectal cancer (CRC) continues to be one of the most common cancers globally. The incidence has increased in developing countries in the past few decades, this could be partly attributed to aging populations and unhealthy lifestyles. While the treatment of CRC has seen significant improvement since the advent of target-specific therapies and personalized medicine, CRC is oftentimes detected at late or advanced stages, thereby reducing the efficacy of treatment. Hence, screening for early detection is still the key to combat CRC and to increase overall survival (OS). Considering that the field of medical diagnostics is moving towards molecular diagnostics, CRC can now be effectively screened and diagnosed with high accuracy and sensitivity. Depending on the tumor genotype and genetic profile of the individual, personalized treatments including tyrosine kinase inhibitor therapy and immunotherapy can be administered. Notably, there can be no one single treatment that is effective for all CRC patients due to the variation in tumor genetics, which highlights the importance of molecular diagnostics. This review provides insights on therapeutic modalities, molecular biomarkers, advancement of diagnostic technologies, and current challenges in managing CRC. MDPI 2019-12-12 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1198/1/Teow%20Sin%20Yeang%20Current%20update%20of%20laboratory%20molecular%20diagnostics%20advancesment%20in%20management%20of%20colorectal%20cancer%20%28CRC%29.pdf Pang, Siew Wai * and Awi, Noel Jacques * and Armon, Subasri and Lim, Wendy Wan-Dee and Low, John Seng-Hooi and Peh, Kaik-Boo and Peh, Suat Cheng * and Teow, Sin Yeang * (2019) Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC). Diagnostics, 10 (1). p. 9. ISSN 2075-4418 http://doi.org/10.3390/diagnostics10010009 doi:10.3390/diagnostics10010009 |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology Pang, Siew Wai * Awi, Noel Jacques * Armon, Subasri Lim, Wendy Wan-Dee Low, John Seng-Hooi Peh, Kaik-Boo Peh, Suat Cheng * Teow, Sin Yeang * Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC) |
| title | Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC) |
| title_full | Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC) |
| title_fullStr | Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC) |
| title_full_unstemmed | Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC) |
| title_short | Current update of laboratory molecular diagnostics advancement in management of colorectal cancer (CRC) |
| title_sort | current update of laboratory molecular diagnostics advancement in management of colorectal cancer (crc) |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) RM Therapeutics. Pharmacology |
| url | http://eprints.sunway.edu.my/1198/ http://eprints.sunway.edu.my/1198/ http://eprints.sunway.edu.my/1198/ http://eprints.sunway.edu.my/1198/1/Teow%20Sin%20Yeang%20Current%20update%20of%20laboratory%20molecular%20diagnostics%20advancesment%20in%20management%20of%20colorectal%20cancer%20%28CRC%29.pdf |