Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering
Electrospinning is a common method to prepare nanofiber scaffolds for tissue engineering. One of the common cellulose esters, cellulose acetate butyrate (CAB), has been electrospun into nanofibers and studied. However, the intrinsic hydrophobicity of CAB limits its application in tissue engineering...
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Elsevier
2020
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| Online Access: | http://eprints.sunway.edu.my/1197/ |
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| author | Tan, Hui Li Kai, Dan Pasbakhsh, Pooria Teow, Sin Yeang * Lim, Yau Yan Pushpamalar, Janarthanan |
| author_facet | Tan, Hui Li Kai, Dan Pasbakhsh, Pooria Teow, Sin Yeang * Lim, Yau Yan Pushpamalar, Janarthanan |
| author_sort | Tan, Hui Li |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Electrospinning is a common method to prepare nanofiber scaffolds for tissue engineering. One of the common cellulose esters, cellulose acetate butyrate (CAB), has been electrospun into nanofibers and studied. However, the intrinsic hydrophobicity of CAB limits its application in tissue engineering as it retards cell adhesion. In this study, the properties of CAB nanofibers were improved by fabricating the composite nanofibers made of CAB and hydrophilic polyethylene glycol (PEG). Different ratios of CAB to PEG were tested and only the ratio of 2:1 resulted in smooth and bead-free nanofibers. The tensile test results show that CAB/PEG composite nanofibers have 2-fold higher tensile strength than pure CAB nanofibers. The hydrophobicity of the composite nanofibers was also reduced based on the water contact angle analysis. As the hydrophilicity increases, the swelling ability of the composite nanofiber increases by 2-fold with more rapid biodegradation. The biocompatibility of the nanofibers was tested with normal human dermal fibroblasts (NHDF). The cell viability assay results revealed that the nanofibers are non-toxic. In addition to that, CAB/PEG nanofibers have better cell attachment compared to pure CAB nanofibers. Based on this study, CAB/PEG composite nanofibers could potentially be used as a nanofiber scaffold for applications in tissue engineering. |
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| format | Article |
| id | sunway-1197 |
| institution | Sunway University |
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| last_indexed | 2025-11-14T21:16:20Z |
| publishDate | 2020 |
| publisher | Elsevier |
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| spelling | sunway-11972019-12-31T01:40:58Z http://eprints.sunway.edu.my/1197/ Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering Tan, Hui Li Kai, Dan Pasbakhsh, Pooria Teow, Sin Yeang * Lim, Yau Yan Pushpamalar, Janarthanan QH301 Biology Electrospinning is a common method to prepare nanofiber scaffolds for tissue engineering. One of the common cellulose esters, cellulose acetate butyrate (CAB), has been electrospun into nanofibers and studied. However, the intrinsic hydrophobicity of CAB limits its application in tissue engineering as it retards cell adhesion. In this study, the properties of CAB nanofibers were improved by fabricating the composite nanofibers made of CAB and hydrophilic polyethylene glycol (PEG). Different ratios of CAB to PEG were tested and only the ratio of 2:1 resulted in smooth and bead-free nanofibers. The tensile test results show that CAB/PEG composite nanofibers have 2-fold higher tensile strength than pure CAB nanofibers. The hydrophobicity of the composite nanofibers was also reduced based on the water contact angle analysis. As the hydrophilicity increases, the swelling ability of the composite nanofiber increases by 2-fold with more rapid biodegradation. The biocompatibility of the nanofibers was tested with normal human dermal fibroblasts (NHDF). The cell viability assay results revealed that the nanofibers are non-toxic. In addition to that, CAB/PEG nanofibers have better cell attachment compared to pure CAB nanofibers. Based on this study, CAB/PEG composite nanofibers could potentially be used as a nanofiber scaffold for applications in tissue engineering. Elsevier 2020-12-09 Article PeerReviewed Tan, Hui Li and Kai, Dan and Pasbakhsh, Pooria and Teow, Sin Yeang * and Lim, Yau Yan and Pushpamalar, Janarthanan (2020) Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering. Colloids and Surfaces B: Biointerfaces, 188. p. 110713. ISSN 0927 7765 http://doi.org/10.1016/j.colsurfb.2019.110713 doi:10.1016/j.colsurfb.2019.110713 |
| spellingShingle | QH301 Biology Tan, Hui Li Kai, Dan Pasbakhsh, Pooria Teow, Sin Yeang * Lim, Yau Yan Pushpamalar, Janarthanan Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering |
| title | Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering |
| title_full | Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering |
| title_fullStr | Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering |
| title_full_unstemmed | Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering |
| title_short | Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: A potential scaffold for tissue engineering |
| title_sort | electrospun cellulose acetate butyrate/polyethylene glycol (cab/peg) composite nanofibers: a potential scaffold for tissue engineering |
| topic | QH301 Biology |
| url | http://eprints.sunway.edu.my/1197/ http://eprints.sunway.edu.my/1197/ http://eprints.sunway.edu.my/1197/ |