Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections

Catheter-associated urinary tract infections (CAUTI) has become an alarming hospital based disease with the increase of multidrug resistance (MDR) strains of Proteus mirabilis. High prevalence of long-term hospital based CAUTI for patients along with moderate percentage of morbidity due to ignorance...

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Main Authors:	Pawar, Shrikant, Ashraf, Md. Izhar, Mujawar, Shama , Lahiri, Chandrajit
Format:	Conference or Workshop Item
Language:	English
Published:	2018
Subjects:	QR355 Virology
Online Access:	http://eprints.sunway.edu.my/1189/ http://eprints.sunway.edu.my/1189/1/Lahiri%202-14.pdf

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author	Pawar, Shrikant Ashraf, Md. Izhar Mujawar, Shama * Lahiri, Chandrajit *
author_facet	Pawar, Shrikant Ashraf, Md. Izhar Mujawar, Shama * Lahiri, Chandrajit *
author_sort	Pawar, Shrikant
building	SU Institutional Repository
collection	Online Access
description	Catheter-associated urinary tract infections (CAUTI) has become an alarming hospital based disease with the increase of multidrug resistance (MDR) strains of Proteus mirabilis. High prevalence of long-term hospital based CAUTI for patients along with moderate percentage of morbidity due to ignorance, failure and MDR, necessitates an immediate intervention strategy to combat the deadly disease. Several reports and reviews focus on revealing the important genes and proteins essential to tackle CAUTI caused by P. mirabilis. Despite longitudinal studies and methodical strategies to circumvent the issues, effective means of unearthing the most influential proteins to target for therapeutic uses have been meagre. Here we have reported a strategic approach for identifying the most influential proteins from the complete set of proteins of the whole genome of P. mirabilis, besides comparing the interactomes comprising the autoinducer-2 (AI-2) biosynthetic pathway along with other proteins involved in biofilm formation and responsible for virulence. Essentially, we have adopted a computational network model based approach to construct a set of small protein interaction networks (SPIN) along with the whole genome (GPIN) to identify, albeit theoretically, the most significant proteins. These might actually be responsible for the phenomenon of quorum sensing (QS) and biofilm formation and thus, could be therapeutically targeted to fight out the 188 MDR threats to antibiotics of P. mirabilis. Our approach signifies the eigenvector centrality coupled with k-core analyses to be a better measure in addressing the pressing issues.
first_indexed	2025-11-14T21:16:18Z
format	Conference or Workshop Item
id	sunway-1189
institution	Sunway University
institution_category	Local University
language	English
last_indexed	2025-11-14T21:16:18Z
publishDate	2018
recordtype	eprints
repository_type	Digital Repository
spelling	sunway-11892019-12-20T02:49:30Z http://eprints.sunway.edu.my/1189/ Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections Pawar, Shrikant Ashraf, Md. Izhar Mujawar, Shama * Lahiri, Chandrajit * QR355 Virology Catheter-associated urinary tract infections (CAUTI) has become an alarming hospital based disease with the increase of multidrug resistance (MDR) strains of Proteus mirabilis. High prevalence of long-term hospital based CAUTI for patients along with moderate percentage of morbidity due to ignorance, failure and MDR, necessitates an immediate intervention strategy to combat the deadly disease. Several reports and reviews focus on revealing the important genes and proteins essential to tackle CAUTI caused by P. mirabilis. Despite longitudinal studies and methodical strategies to circumvent the issues, effective means of unearthing the most influential proteins to target for therapeutic uses have been meagre. Here we have reported a strategic approach for identifying the most influential proteins from the complete set of proteins of the whole genome of P. mirabilis, besides comparing the interactomes comprising the autoinducer-2 (AI-2) biosynthetic pathway along with other proteins involved in biofilm formation and responsible for virulence. Essentially, we have adopted a computational network model based approach to construct a set of small protein interaction networks (SPIN) along with the whole genome (GPIN) to identify, albeit theoretically, the most significant proteins. These might actually be responsible for the phenomenon of quorum sensing (QS) and biofilm formation and thus, could be therapeutically targeted to fight out the 188 MDR threats to antibiotics of P. mirabilis. Our approach signifies the eigenvector centrality coupled with k-core analyses to be a better measure in addressing the pressing issues. 2018-07 Conference or Workshop Item PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1189/1/Lahiri%202-14.pdf Pawar, Shrikant and Ashraf, Md. Izhar and Mujawar, Shama * and Lahiri, Chandrajit * (2018) Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections. In: International Conference on Complex Systems 2018, 22-27 July 2018, New England Complex Systems Institute, Cambridge, USA.. https://necsi.edu/iccs-2018
spellingShingle	QR355 Virology Pawar, Shrikant Ashraf, Md. Izhar Mujawar, Shama * Lahiri, Chandrajit * Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections
title	Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections
title_full	Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections
title_fullStr	Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections
title_full_unstemmed	Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections
title_short	Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections
title_sort	influential quorum sensing proteins of multidrug resistant proteus mirabilis causing urinary tract infections
topic	QR355 Virology
url	http://eprints.sunway.edu.my/1189/ http://eprints.sunway.edu.my/1189/ http://eprints.sunway.edu.my/1189/1/Lahiri%202-14.pdf

Influential Quorum Sensing Proteins of multidrug resistant Proteus mirabilis causing urinary tract infections

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