A one-pot synthesis of N2,6-diaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines and systematic evaluation of their ability to host ethanol in crystals

QR Code

A one-pot synthesis of N2,6-diaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines and systematic evaluation of their ability to host ethanol in crystals

A convenient one-pot method for the preparation of N2 ,6-diaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines was developed using a three-component synthesis of 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines followed by their Dimroth rearrangement to the desired products. The prepared compounds crys...

Full description

Bibliographic Details
Main Authors:	Ahmad Junaid, Tan, Yee Seng , Tiekink, Edward R. T. , Dolzhenko, Anton V
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2019
Subjects:	QD Chemistry
Online Access:	http://eprints.sunway.edu.my/1126/ http://eprints.sunway.edu.my/1126/1/Tiekink%20A%20one%20pot%20synthesis%20RSC%20Adv%202019%209%2037660.pdf

Similar Items

Synthesis and tautomerism study of 6-benzoylmethyl-1,3,5-triazin-2,4-diamine
by: Sachdeva, N., et al.
Published: (2011)

Ethanol- and heat-mediated phase change from a kinetic (Z′ = 4) polymorph to a thermodynamic (Z′ = 1) polymorph for an N2,6-diaryl-1,3,5-triazine-2,4-diamine
by: Tan, Sang Loon *, et al.
Published: (2023)

Design, synthesis, and biological evaluation of new 6,N2-diaryl-1,3,5-triazine-2,4-diamines as anticancer agents selectively targeting triple negative breast cancer cells
by: Ahmad Junaid,, et al.
Published: (2020)

Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines
by: Dolzhenko, Anton, et al.
Published: (2007)

7,7-Dimethyl-2-phenyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine.
by: Dolzhenko, Anton, et al.
Published: (2007)

Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines.
by: Dolzhenko, Anton, et al.
Published: (2008)

A New one-pot three-component synthesis of 4-Aryl-6-cycloamino-1,3,5-triazin-2-amines under microwave irradiation
by: Muhammad Syafiq, S, et al.
Published: (2021)

Molecular and Crystal Structure of 7,7-Dimethyl-2-pyridin-4-yl-6,7-dihydro-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine [1]
by: Dolzhenko, Anton, et al.
Published: (2011)

4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one
by: Smolnikov, S., et al.
Published: (2017)

4-Amino-2,8-dimethyl-6H-pyrimido[1,2-a][1,3,5]triazin-6-one
by: Sachdeva, N., et al.
Published: (2010)

Synthesis of 5,7-Diamino[1,2,4]triazolo[1,2-a][1,3,5]triazines via Annulation of 1,3,5-Triazine Ring onto 3(5)-Amino-1,2,4-trizoles
by: Dolzhenko, Anton, et al.
Published: (2007)

An efficient synthesis of 2,4,7-trisubstituted pyrimido[1,2-a][1,3,5]triazin-6-ones
by: Sachdeva, N., et al.
Published: (2015)

Simple synthesis of 2-amino-4-(het)aryl-4,6-dihydro-1(3)(11)H-[1,3,5]triazino[2,1-b]quinazolin-6-ones
by: Dolzhenko, Anton, et al.
Published: (2008)

Synthetic routes towards pyrimido[1,2-a][1,3,5]triazines (Review)
by: Dolzhenko, Anton
Published: (2011)

New One-Pot Synthesis of 1,3,5-Triazines: Three-Component Condensation, Dimroth Rearrangement, and Dehydrogenative Aromatization
by: Ahmad Junaid,, et al.
Published: (2019)

One-pot multicomponent synthesis of bis(diamino-1,3,5-triazines) under microwave irradiation.
by: Muhammad Syafiq, Sahari, et al.
Published: (2022)

Synthetic Routes towards Thiazolo[1,3,5]triazines (Review)
by: Dolzhenko, Anton
Published: (2011)

Advances in chemistry and biological activity of fluorinated 1,3,5-triazines
by: Dolzhenko, Anton, et al.
Published: (2007)

Advances in chemistry and biological activity of fluorinated 1,3,5-triazines
by: Dolzhenko, Anton, et al.
Published: (2012)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines
by: Lim, F., et al.
Published: (2018)

2-Amino-4-(4-bromophenyl)-8-trifluoromethyl-3,4-dihydropyrimido[1,2-a][1,3,5]triazin-6(5H)-one
by: Dolzhenko, Anton, et al.
Published: (2009)

A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines
by: Kalinina, S., et al.
Published: (2013)

Regioselective synthesis of pyrimido [1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethylorthoacetate: Observation of an unexpected rearrangement
by: Sachdeva, N., et al.
Published: (2012)

Synthesis of novel trichloromethyl substituted azolo[1,3,5]triazines
by: Kalinin, D., et al.
Published: (2012)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
by: Lim, Felicia Phei Lin, et al.
Published: (2018)

Pyrazolo[1,5-a][1,3,5]triazines(5-Aza-9-deazapurines): Synthesis and Biological Activity
by: Dolzhenko, Anton, et al.
Published: (2008)

Synthesis and structure of 3,4-dihydropyrido[2’,3’:3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amines
by: Dolzhenko, Anton, et al.
Published: (2012)

7-(4-Fluorobenzylamino)-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol disolvate
by: Dolzhenko, Anton, et al.
Published: (2011)

2-Phenyl-7-(4-pyridylmethylamino)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5(4H)-one
by: Dolzhenko, Anton, et al.
Published: (2011)

Method of obtaining condensed gem-dimethyl substituted amino-1,3,5-triazines
by: Dolzhenko, Anton, et al.
Published: (2007)

7-Dimethylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol solvate.
by: Dolzhenko, Anton, et al.
Published: (2008)

Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines
by: Dolzhenko, Anton, et al.
Published: (2015)

6-Amino-3,4-dimethyl-1,2,4-triazin-1-ium 2-anilinobenzoate–3-amino-5,6-dimethyl-1,2,4-triazine (1/1)
by: Sangeetha, Ramalingam, et al.
Published: (2017)

6-Amino-3,4-dimethyl-1,2,4-triazin-1-ium 2-anilinobenzoate–3-amino-5,6-dimethyl-1,2,4- triazine (1/1)
by: Sangeetha, Ramalingam, et al.
Published: (2017)

A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles
by: Lim, F., et al.
Published: (2015)

4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

4,4-Dimethyl-3,4-dihydropyrido[2',3':3,4]pyrazolo[1,5-a ][1,3,5]triazin-2-amine ethanol monosolvate
by: Dolzhenko, Anton, et al.
Published: (2011)

Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors
by: Bera, H., et al.
Published: (2013)

1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

2-[(4-Chlorophenyl)selanyl]-3,4-dihydro-2H-benzo[h]chromene-5,6-dione: crystal structure and Hirshfeld analysis
by: Zukerman-Schpector, Julio, et al.
Published: (2017)