A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence
Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute faccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genome...
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Nature Research
2019
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| Online Access: | http://eprints.sunway.edu.my/1098/ http://eprints.sunway.edu.my/1098/1/Poh%20CL_A%20decade%20of%20sustained%20selection%20pressure%20on%20two.pdf |
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| author | Roberts, Ryan Yee, Isabel Pin Tsin * Mujawar, Shama * Lahiri, Chandrajit * Poh, Chit Laa * Gatherer, Derek |
| author_facet | Roberts, Ryan Yee, Isabel Pin Tsin * Mujawar, Shama * Lahiri, Chandrajit * Poh, Chit Laa * Gatherer, Derek |
| author_sort | Roberts, Ryan |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute faccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection dates from 2008 to mid-2018. All sub-genotypes exhibit a strong molecular
clock with omega (dN/dS) suggesting strong purifying selection. In sub-genotypes B5 and C4, positive
selection can be detected at two surface sites on the VP1 protein, also detected in positive selection studies performed prior to 2008. Toggling of a limited repertoire of amino acids at these positively selected residues over the last decade suggests that EV-A71 may be undergoing a sustained frequencydependent selection process for immune evasion, raising issues for vaccine development. These same sites have also been previously implicated in virus-host binding and strain-associated severity of HFMD,
suggesting that immune evasion may be an indirect driver for virulence (154 words). |
| first_indexed | 2025-11-14T21:15:58Z |
| format | Article |
| id | sunway-1098 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:15:58Z |
| publishDate | 2019 |
| publisher | Nature Research |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-10982020-10-12T07:53:49Z http://eprints.sunway.edu.my/1098/ A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence Roberts, Ryan Yee, Isabel Pin Tsin * Mujawar, Shama * Lahiri, Chandrajit * Poh, Chit Laa * Gatherer, Derek QR355 Virology Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute faccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection dates from 2008 to mid-2018. All sub-genotypes exhibit a strong molecular clock with omega (dN/dS) suggesting strong purifying selection. In sub-genotypes B5 and C4, positive selection can be detected at two surface sites on the VP1 protein, also detected in positive selection studies performed prior to 2008. Toggling of a limited repertoire of amino acids at these positively selected residues over the last decade suggests that EV-A71 may be undergoing a sustained frequencydependent selection process for immune evasion, raising issues for vaccine development. These same sites have also been previously implicated in virus-host binding and strain-associated severity of HFMD, suggesting that immune evasion may be an indirect driver for virulence (154 words). Nature Research 2019-04-01 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1098/1/Poh%20CL_A%20decade%20of%20sustained%20selection%20pressure%20on%20two.pdf Roberts, Ryan and Yee, Isabel Pin Tsin * and Mujawar, Shama * and Lahiri, Chandrajit * and Poh, Chit Laa * and Gatherer, Derek (2019) A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence. Scientific Reports, 9 (1). pp. 1-9. ISSN 2045-2322 http://doi.org/10.1038/s41598-019-41662-8 doi:10.1038/s41598-019-41662-8 |
| spellingShingle | QR355 Virology Roberts, Ryan Yee, Isabel Pin Tsin * Mujawar, Shama * Lahiri, Chandrajit * Poh, Chit Laa * Gatherer, Derek A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence |
| title | A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence |
| title_full | A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence |
| title_fullStr | A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence |
| title_full_unstemmed | A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence |
| title_short | A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence |
| title_sort | decade of sustained selection pressure on two surface sites of the vp1 protein of enterovirus a71 suggests that immune evasion may be an indirect driver for virulence |
| topic | QR355 Virology |
| url | http://eprints.sunway.edu.my/1098/ http://eprints.sunway.edu.my/1098/ http://eprints.sunway.edu.my/1098/ http://eprints.sunway.edu.my/1098/1/Poh%20CL_A%20decade%20of%20sustained%20selection%20pressure%20on%20two.pdf |