The conserved molecular determinants of virulence in dengue virus
Dengue virus belongs to the Flaviviridae family which also includes viruses such as the Zika, West Nile and yellow fever virus. Dengue virus generally causes mild disease, however, more severe forms of the dengue virus infection, dengue haemorrhagic fever (DHF) and dengue haemorrhagic fever with sh...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ivyspring International Publisher
2019
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/1096/ http://eprints.sunway.edu.my/1096/1/Prof.%20Poh_The%20Conserved%20Molecular%20Determinants.pdf |
| _version_ | 1848801972985004032 |
|---|---|
| author | Zuleeza A, Poh, Chit Laa * |
| author_facet | Zuleeza A, Poh, Chit Laa * |
| author_sort | Zuleeza A, |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Dengue virus belongs to the Flaviviridae family which also includes viruses such as the Zika, West Nile and yellow fever virus. Dengue virus generally causes mild disease, however, more severe forms of the dengue virus infection, dengue haemorrhagic fever (DHF) and dengue haemorrhagic
fever with shock syndrome (DSS) can also occur, resulting in multiple organ failure and even death, especially in children. The only dengue vaccine available in the market, CYD-TDV offers limited coverage for vaccinees from 9-45 years of age and is only recommended for individuals with prior dengue exposure. A number of mutations that were shown to attenuate virulence of dengue virus in
vitro and/or in vivo have been identified in the literature. The mutations which fall within the
conserved regions of all four dengue serotypes are discussed. This review hopes to provide information leading to the construction of a live attenuated dengue vaccine that is suitable for all ages, irrespective of the infecting dengue serotype and prior dengue exposure. |
| first_indexed | 2025-11-14T21:15:57Z |
| format | Article |
| id | sunway-1096 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:15:57Z |
| publishDate | 2019 |
| publisher | Ivyspring International Publisher |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-10962019-09-06T09:27:02Z http://eprints.sunway.edu.my/1096/ The conserved molecular determinants of virulence in dengue virus Zuleeza A, Poh, Chit Laa * QR355 Virology Dengue virus belongs to the Flaviviridae family which also includes viruses such as the Zika, West Nile and yellow fever virus. Dengue virus generally causes mild disease, however, more severe forms of the dengue virus infection, dengue haemorrhagic fever (DHF) and dengue haemorrhagic fever with shock syndrome (DSS) can also occur, resulting in multiple organ failure and even death, especially in children. The only dengue vaccine available in the market, CYD-TDV offers limited coverage for vaccinees from 9-45 years of age and is only recommended for individuals with prior dengue exposure. A number of mutations that were shown to attenuate virulence of dengue virus in vitro and/or in vivo have been identified in the literature. The mutations which fall within the conserved regions of all four dengue serotypes are discussed. This review hopes to provide information leading to the construction of a live attenuated dengue vaccine that is suitable for all ages, irrespective of the infecting dengue serotype and prior dengue exposure. Ivyspring International Publisher 2019-01-24 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1096/1/Prof.%20Poh_The%20Conserved%20Molecular%20Determinants.pdf Zuleeza A, and Poh, Chit Laa * (2019) The conserved molecular determinants of virulence in dengue virus. International Journal of Medical Sciences, 16 (3). pp. 355-365. ISSN 1449-1907 www.medsci.org doi: 10.7150/ijms.29938 |
| spellingShingle | QR355 Virology Zuleeza A, Poh, Chit Laa * The conserved molecular determinants of virulence in dengue virus |
| title | The conserved molecular determinants of virulence in
dengue virus |
| title_full | The conserved molecular determinants of virulence in
dengue virus |
| title_fullStr | The conserved molecular determinants of virulence in
dengue virus |
| title_full_unstemmed | The conserved molecular determinants of virulence in
dengue virus |
| title_short | The conserved molecular determinants of virulence in
dengue virus |
| title_sort | conserved molecular determinants of virulence in
dengue virus |
| topic | QR355 Virology |
| url | http://eprints.sunway.edu.my/1096/ http://eprints.sunway.edu.my/1096/ http://eprints.sunway.edu.my/1096/ http://eprints.sunway.edu.my/1096/1/Prof.%20Poh_The%20Conserved%20Molecular%20Determinants.pdf |