Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease
Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a nee...
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MDPI
2019
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| Online Access: | http://eprints.sunway.edu.my/1094/ http://eprints.sunway.edu.my/1094/1/Prof.%20Poh_Advances%20in%20Antigenic%20Peptide-Based%20Vaccine.pdf |
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| author | Mohd Ishtiaq Anasir, * Poh, Chit Laa * |
| author_facet | Mohd Ishtiaq Anasir, * Poh, Chit Laa * |
| author_sort | Mohd Ishtiaq Anasir, * |
| building | SU Institutional Repository |
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| description | Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and
Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents,
such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic
peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis
for the design of future therapies against HFMD etiological agents. |
| first_indexed | 2025-11-14T21:15:57Z |
| format | Article |
| id | sunway-1094 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:15:57Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-10942019-09-19T01:59:24Z http://eprints.sunway.edu.my/1094/ Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease Mohd Ishtiaq Anasir, * Poh, Chit Laa * QR355 Virology Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents, such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis for the design of future therapies against HFMD etiological agents. MDPI 2019-03-13 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1094/1/Prof.%20Poh_Advances%20in%20Antigenic%20Peptide-Based%20Vaccine.pdf Mohd Ishtiaq Anasir, * and Poh, Chit Laa * (2019) Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease. International Journal of Molecular Sciences, 20 (6). p. 1256. ISSN 1422-0067 http://doi.org/10.3390/ijms20061256 doi:10.3390/ijms20061256 |
| spellingShingle | QR355 Virology Mohd Ishtiaq Anasir, * Poh, Chit Laa * Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease |
| title | Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease |
| title_full | Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease |
| title_fullStr | Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease |
| title_full_unstemmed | Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease |
| title_short | Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease |
| title_sort | advances in antigenic peptide-based vaccine and neutralizing antibodies against viruses causing hand, foot, and mouth disease |
| topic | QR355 Virology |
| url | http://eprints.sunway.edu.my/1094/ http://eprints.sunway.edu.my/1094/ http://eprints.sunway.edu.my/1094/ http://eprints.sunway.edu.my/1094/1/Prof.%20Poh_Advances%20in%20Antigenic%20Peptide-Based%20Vaccine.pdf |