Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer
Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development w...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2019
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| Online Access: | http://eprints.sunway.edu.my/1093/ http://eprints.sunway.edu.my/1093/1/Poh%20CL_Oncogenic%20Signaling%20in%20Tumorigenesis%20and%20Applications.pdf |
| _version_ | 1848801972138803200 |
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| author | Nur Izyani K, Noraini Abd Aziz, * Poh, Chit Laa * Chowdhury, Ezharul Hoque |
| author_facet | Nur Izyani K, Noraini Abd Aziz, * Poh, Chit Laa * Chowdhury, Ezharul Hoque |
| author_sort | Nur Izyani K, |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease.
Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential
therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated
signaling pathways. |
| first_indexed | 2025-11-14T21:15:56Z |
| format | Article |
| id | sunway-1093 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:15:56Z |
| publishDate | 2019 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-10932019-09-06T09:25:19Z http://eprints.sunway.edu.my/1093/ Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer Nur Izyani K, Noraini Abd Aziz, * Poh, Chit Laa * Chowdhury, Ezharul Hoque RC0254 Neoplasms. Tumors. Oncology (including Cancer) Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated signaling pathways. MDPI 2019-05-06 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1093/1/Poh%20CL_Oncogenic%20Signaling%20in%20Tumorigenesis%20and%20Applications.pdf Nur Izyani K, and Noraini Abd Aziz, * and Poh, Chit Laa * and Chowdhury, Ezharul Hoque (2019) Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer. Cancers, 11 (5). p. 632. ISSN 2072-6694 http://doi.org/10.3390/cancers11050632 doi:10.3390/cancers11050632 |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Nur Izyani K, Noraini Abd Aziz, * Poh, Chit Laa * Chowdhury, Ezharul Hoque Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer |
| title | Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer |
| title_full | Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer |
| title_fullStr | Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer |
| title_full_unstemmed | Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer |
| title_short | Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer |
| title_sort | oncogenic signaling in tumorigenesis and applications of sirna nanotherapeutics in breast cancer |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/1093/ http://eprints.sunway.edu.my/1093/ http://eprints.sunway.edu.my/1093/ http://eprints.sunway.edu.my/1093/1/Poh%20CL_Oncogenic%20Signaling%20in%20Tumorigenesis%20and%20Applications.pdf |