A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism
It was found that 3-amino-substituted 5-aminopyrazoles could be effectively prepared via hydrolytic decarboxylation of the corresponding 3,5-diaminopyrazole-4-carboxylates 5 under microwave irradiation. The reactions required short time (4 min) and were successfully reproduced in a larger scale and...
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| Format: | Article |
| Language: | English |
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Elsevier
2019
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| Online Access: | http://eprints.sunway.edu.my/1021/ http://eprints.sunway.edu.my/1021/1/Tiekink%20A%20New%20Practical%20Synthesis%20of%203-amino%20Tetrahedron%202019%2075%202314_acc.pdf |
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| author | Phei, Felicia Lin Lim Tan, Khai Ching Luna, Giuseppe Tiekink, Edward R. T. * Dolzhenko, Anton V |
| author_facet | Phei, Felicia Lin Lim Tan, Khai Ching Luna, Giuseppe Tiekink, Edward R. T. * Dolzhenko, Anton V |
| author_sort | Phei, Felicia Lin Lim |
| building | SU Institutional Repository |
| collection | Online Access |
| description | It was found that 3-amino-substituted 5-aminopyrazoles could be effectively prepared via
hydrolytic decarboxylation of the corresponding 3,5-diaminopyrazole-4-carboxylates 5 under microwave irradiation. The reactions required short time (4 min) and were successfully reproduced in a larger scale and under conventional heating mimicking the microwave heating pattern. X-ray crystallography identified two different types of tautomers in crystals of related 5-aminopyrazoles with p-toluidyl and p-anisidyl moieties at the position 3, respectively. |
| first_indexed | 2025-11-14T21:15:28Z |
| format | Article |
| id | sunway-1021 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:15:28Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-10212020-10-07T08:42:13Z http://eprints.sunway.edu.my/1021/ A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism Phei, Felicia Lin Lim Tan, Khai Ching Luna, Giuseppe Tiekink, Edward R. T. * Dolzhenko, Anton V QD Chemistry It was found that 3-amino-substituted 5-aminopyrazoles could be effectively prepared via hydrolytic decarboxylation of the corresponding 3,5-diaminopyrazole-4-carboxylates 5 under microwave irradiation. The reactions required short time (4 min) and were successfully reproduced in a larger scale and under conventional heating mimicking the microwave heating pattern. X-ray crystallography identified two different types of tautomers in crystals of related 5-aminopyrazoles with p-toluidyl and p-anisidyl moieties at the position 3, respectively. Elsevier 2019-04-12 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/1021/1/Tiekink%20A%20New%20Practical%20Synthesis%20of%203-amino%20Tetrahedron%202019%2075%202314_acc.pdf Phei, Felicia Lin Lim and Tan, Khai Ching and Luna, Giuseppe and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2019) A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism. Tetrahedron, 75 (15). pp. 2314-2321. ISSN 0040-4020 https://doi.org/10.1016/j.tet.2019.03.003 |
| spellingShingle | QD Chemistry Phei, Felicia Lin Lim Tan, Khai Ching Luna, Giuseppe Tiekink, Edward R. T. * Dolzhenko, Anton V A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism |
| title | A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism |
| title_full | A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism |
| title_fullStr | A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism |
| title_full_unstemmed | A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism |
| title_short | A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism |
| title_sort | new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/1021/ http://eprints.sunway.edu.my/1021/ http://eprints.sunway.edu.my/1021/1/Tiekink%20A%20New%20Practical%20Synthesis%20of%203-amino%20Tetrahedron%202019%2075%202314_acc.pdf |