A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism
It was found that 3-amino-substituted 5-aminopyrazoles could be effectively prepared via hydrolytic decarboxylation of the corresponding 3,5-diaminopyrazole-4-carboxylates 5 under microwave irradiation. The reactions required short time (4 min) and were successfully reproduced in a larger scale and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019
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| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/1021/ http://eprints.sunway.edu.my/1021/1/Tiekink%20A%20New%20Practical%20Synthesis%20of%203-amino%20Tetrahedron%202019%2075%202314_acc.pdf |
| Summary: | It was found that 3-amino-substituted 5-aminopyrazoles could be effectively prepared via
hydrolytic decarboxylation of the corresponding 3,5-diaminopyrazole-4-carboxylates 5 under microwave irradiation. The reactions required short time (4 min) and were successfully reproduced in a larger scale and under conventional heating mimicking the microwave heating pattern. X-ray crystallography identified two different types of tautomers in crystals of related 5-aminopyrazoles with p-toluidyl and p-anisidyl moieties at the position 3, respectively. |
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