Independent component analysis for assessing therapeutic response in vitiligo skin disorder
This paper describes an image analysis technique that objectively measures skin repigmentation for the assessment of therapeutic response in vitiligo treatments. Skin pigment disorders due to the abnormality of melanin production, such as vitiligo, cause irregular pale patches of skin. The therapeut...
| Main Authors: | , , , |
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| Format: | Citation Index Journal |
| Language: | English |
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2009
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| Online Access: | http://scholars.utp.edu.my/id/eprint/416/ http://scholars.utp.edu.my/id/eprint/416/1/paper.pdf |
| _version_ | 1848658980282302464 |
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| author | M.H.A., Fadzil S., Norashikin H.H., Suraiya H., Nugroho |
| author_facet | M.H.A., Fadzil S., Norashikin H.H., Suraiya H., Nugroho |
| author_sort | M.H.A., Fadzil |
| building | UTP Institutional Repository |
| collection | Online Access |
| description | This paper describes an image analysis technique that objectively measures skin repigmentation for the assessment of therapeutic response in vitiligo treatments. Skin pigment disorders due to the abnormality of melanin production, such as vitiligo, cause irregular pale patches of skin. The therapeutic response to treatment is repigmentation of the skin. However the repigmentation process is very slow and is only observable after a few months of treatment. Currently, there is no objective method to assess the therapeutic response of skin pigment disorder treatment, particularly for vitiligo treatment. In this work, we apply principal component analysis followed by independent component analysis to represent digital skin images in terms of melanin and haemoglobin composition respectively. Vitiligo skin areas are identified as skin areas that lack melanin (non-melanin areas). Results obtained using the technique have been verified by dermatologists. Based on 20 patients, the proposed technique effectively monitored the progression of repigmentation over a shorter time period of six weeks and can thus be used to evaluate treatment efficacy objectively and more effectively. © 2009 Informa Healthcare USA, Inc.
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| first_indexed | 2025-11-13T07:23:09Z |
| format | Citation Index Journal |
| id | oai:scholars.utp.edu.my:416 |
| institution | Universiti Teknologi Petronas |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-13T07:23:09Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:scholars.utp.edu.my:4162017-01-19T08:25:48Z http://scholars.utp.edu.my/id/eprint/416/ Independent component analysis for assessing therapeutic response in vitiligo skin disorder M.H.A., Fadzil S., Norashikin H.H., Suraiya H., Nugroho TK Electrical engineering. Electronics Nuclear engineering This paper describes an image analysis technique that objectively measures skin repigmentation for the assessment of therapeutic response in vitiligo treatments. Skin pigment disorders due to the abnormality of melanin production, such as vitiligo, cause irregular pale patches of skin. The therapeutic response to treatment is repigmentation of the skin. However the repigmentation process is very slow and is only observable after a few months of treatment. Currently, there is no objective method to assess the therapeutic response of skin pigment disorder treatment, particularly for vitiligo treatment. In this work, we apply principal component analysis followed by independent component analysis to represent digital skin images in terms of melanin and haemoglobin composition respectively. Vitiligo skin areas are identified as skin areas that lack melanin (non-melanin areas). Results obtained using the technique have been verified by dermatologists. Based on 20 patients, the proposed technique effectively monitored the progression of repigmentation over a shorter time period of six weeks and can thus be used to evaluate treatment efficacy objectively and more effectively. © 2009 Informa Healthcare USA, Inc. 2009 Citation Index Journal NonPeerReviewed application/pdf en http://scholars.utp.edu.my/id/eprint/416/1/paper.pdf M.H.A., Fadzil and S., Norashikin and H.H., Suraiya and H., Nugroho (2009) Independent component analysis for assessing therapeutic response in vitiligo skin disorder. [Citation Index Journal] http://www.scopus.com/inward/record.url?eid=2-s2.0-61649115956&partnerID=40&md5=de9ad61260100257710cfb1f43f91552 10.1080/03091900802454459 10.1080/03091900802454459 10.1080/03091900802454459 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering M.H.A., Fadzil S., Norashikin H.H., Suraiya H., Nugroho Independent component analysis for assessing therapeutic response in vitiligo skin disorder |
| title | Independent component analysis for assessing therapeutic response in vitiligo skin disorder
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| title_full | Independent component analysis for assessing therapeutic response in vitiligo skin disorder
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| title_fullStr | Independent component analysis for assessing therapeutic response in vitiligo skin disorder
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| title_full_unstemmed | Independent component analysis for assessing therapeutic response in vitiligo skin disorder
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| title_short | Independent component analysis for assessing therapeutic response in vitiligo skin disorder
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| title_sort | independent component analysis for assessing therapeutic response in vitiligo skin disorder |
| topic | TK Electrical engineering. Electronics Nuclear engineering |
| url | http://scholars.utp.edu.my/id/eprint/416/ http://scholars.utp.edu.my/id/eprint/416/ http://scholars.utp.edu.my/id/eprint/416/ http://scholars.utp.edu.my/id/eprint/416/1/paper.pdf |