Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress
UKMR-1, a local variant of mutant Roselle strain (Hibiscus sabdariffa) is enriched with free radical scavenging polyphenols such as anthocyanin, vitamin C and hydroxycitric acid. However, pharmacological actions of UKMR-1 are not fully known. This study was conducted to determine whether supplementa...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2016
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| Online Access: | http://journalarticle.ukm.my/9988/ http://journalarticle.ukm.my/9988/1/16%20Anand%20Ramalingam.pdf |
| _version_ | 1848812253078355968 |
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| author | Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin, |
| author_facet | Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin, |
| author_sort | Anand Ramalingam, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | UKMR-1, a local variant of mutant Roselle strain (Hibiscus sabdariffa) is enriched with free radical scavenging polyphenols such as anthocyanin, vitamin C and hydroxycitric acid. However, pharmacological actions of UKMR-1 are not fully known. This study was conducted to determine whether supplementation of aqueous UKMR-1 calyx extract was able to protect against nicotine-induced cardiac injury in rats. In this experimental study, healthy male albino rats were randomly allotted into three groups (n=7 per group): control, nicotine and UKMR-1+Nicotine groups. Nicotine (0.6 mg/kg, i.p.) was administered to both nicotine and UKMR-1+Nicotine groups for 28 consecutive days. UKMR-1+Nicotine group also received 100 mg/kg UKMR-1 extract orally via gavage 30 min prior to nicotine injection, daily. UKMR-1+Nicotine group had significantly (p<0.05) higher lactate dehydrogenase (LDH) activity, as well as lower malondialdehyde content in heart tissue homogenate than nicotine group, suggesting its cardio protective activity by inhibition of lipid peroxidation. UKMR-1 also lowered (p<0.05) the blood pressure in nicotine-administered rats. In addition, UKMR-1 significantly (p<0.05) restored activities of cytosolic superoxide dismutase, glutathione peroxidase and glutathione-S-transferase as well as redox balance ratio (GSH:GSSG). In conclusion, UKMR-1 was able to protect against myocardial injury in rat model of nicotine administration possibly by inhibiting oxidative stress. |
| first_indexed | 2025-11-14T23:59:21Z |
| format | Article |
| id | oai:generic.eprints.org:9988 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:59:21Z |
| publishDate | 2016 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:99882017-01-20T01:08:17Z http://journalarticle.ukm.my/9988/ Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin, UKMR-1, a local variant of mutant Roselle strain (Hibiscus sabdariffa) is enriched with free radical scavenging polyphenols such as anthocyanin, vitamin C and hydroxycitric acid. However, pharmacological actions of UKMR-1 are not fully known. This study was conducted to determine whether supplementation of aqueous UKMR-1 calyx extract was able to protect against nicotine-induced cardiac injury in rats. In this experimental study, healthy male albino rats were randomly allotted into three groups (n=7 per group): control, nicotine and UKMR-1+Nicotine groups. Nicotine (0.6 mg/kg, i.p.) was administered to both nicotine and UKMR-1+Nicotine groups for 28 consecutive days. UKMR-1+Nicotine group also received 100 mg/kg UKMR-1 extract orally via gavage 30 min prior to nicotine injection, daily. UKMR-1+Nicotine group had significantly (p<0.05) higher lactate dehydrogenase (LDH) activity, as well as lower malondialdehyde content in heart tissue homogenate than nicotine group, suggesting its cardio protective activity by inhibition of lipid peroxidation. UKMR-1 also lowered (p<0.05) the blood pressure in nicotine-administered rats. In addition, UKMR-1 significantly (p<0.05) restored activities of cytosolic superoxide dismutase, glutathione peroxidase and glutathione-S-transferase as well as redox balance ratio (GSH:GSSG). In conclusion, UKMR-1 was able to protect against myocardial injury in rat model of nicotine administration possibly by inhibiting oxidative stress. Penerbit Universiti Kebangsaan Malaysia 2016-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9988/1/16%20Anand%20Ramalingam.pdf Anand Ramalingam, and Siti Balkis Budin, and Lim, Yi-Cheng and Si, Yiang-Lislivia Nee and Satirah Zainalabidin, (2016) Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress. Sains Malaysiana, 45 (7). pp. 1131-1137. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol45num7_2016/contentsVol45num7_2016.html |
| spellingShingle | Anand Ramalingam, Siti Balkis Budin, Lim, Yi-Cheng Si, Yiang-Lislivia Nee Satirah Zainalabidin, Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress |
| title | Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress |
| title_full | Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress |
| title_fullStr | Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress |
| title_full_unstemmed | Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress |
| title_short | Dietary UKMR-1 Roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress |
| title_sort | dietary ukmr-1 roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress |
| url | http://journalarticle.ukm.my/9988/ http://journalarticle.ukm.my/9988/ http://journalarticle.ukm.my/9988/1/16%20Anand%20Ramalingam.pdf |