Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats
Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial...
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| Format: | Article |
| Language: | English |
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Penerbit UKM
2015
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| Online Access: | http://journalarticle.ukm.my/9401/ http://journalarticle.ukm.my/9401/1/10876-29609-1-SM.pdf |
| _version_ | 1848812071518470144 |
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| author | Faez Sharif, Muhajir Hamid, Amin Ismail, Zainah Adam, |
| author_facet | Faez Sharif, Muhajir Hamid, Amin Ismail, Zainah Adam, |
| author_sort | Faez Sharif, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats. |
| first_indexed | 2025-11-14T23:56:28Z |
| format | Article |
| id | oai:generic.eprints.org:9401 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:56:28Z |
| publishDate | 2015 |
| publisher | Penerbit UKM |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:94012016-12-14T06:49:49Z http://journalarticle.ukm.my/9401/ Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats Faez Sharif, Muhajir Hamid, Amin Ismail, Zainah Adam, RA Public aspects of medicine Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats. Penerbit UKM 2015 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9401/1/10876-29609-1-SM.pdf Faez Sharif, and Muhajir Hamid, and Amin Ismail, and Zainah Adam, (2015) Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats. Jurnal Sains Kesihatan Malaysia, 13 (2). pp. 37-43. ISSN 1675-8161 http://ejournal.ukm.my/jskm/article/view/10876 |
| spellingShingle | RA Public aspects of medicine Faez Sharif, Muhajir Hamid, Amin Ismail, Zainah Adam, Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats |
| title | Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats |
| title_full | Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats |
| title_fullStr | Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats |
| title_full_unstemmed | Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats |
| title_short | Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats |
| title_sort | antihyperglycemic activity of oil palm elaeis guineensis fruit extract on streptozotocin-induced diabetic rats |
| topic | RA Public aspects of medicine |
| url | http://journalarticle.ukm.my/9401/ http://journalarticle.ukm.my/9401/ http://journalarticle.ukm.my/9401/1/10876-29609-1-SM.pdf |