In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones
Glaciozyma antarctica is a psychrophilic yeast isolated from the Antarctic sea ice. In this study, we performed a de novo characterisation of molecular chaperones from G. antarctica genome datasets. A total of 7857 genes that code for various types of proteins have been predicted from the G. antar...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2015
|
| Online Access: | http://journalarticle.ukm.my/8724/ http://journalarticle.ukm.my/8724/1/44_1_26.pdf |
| _version_ | 1848811878408519680 |
|---|---|
| author | Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A. |
| author_facet | Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A. |
| author_sort | Nur Athirah, Y. |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Glaciozyma antarctica is a psychrophilic yeast isolated from the Antarctic sea ice. In this study, we performed a de novo
characterisation of molecular chaperones from G. antarctica genome datasets. A total of 7857 genes that code for various
types of proteins have been predicted from the G. antarctica genome sequence. From these genes, we identified 89 possible
molecular chaperones that matched known molecular chaperones from other organisms available in various databases such as
Uniprot, Gene Ontology, cpnDB and NCBI. For an in-depth analysis of molecular functions, we used homologous clustering
to transfer knowledge from unknown to known functions using Cluster Analysis of Sequences (CLANS) bioinformatics
software. The results reveal 12 major groups of chaperones that contribute to the cold-adaptation mechanism through their
molecular function, biological processes and cellular components. The findings lay the foundation for future functional genomics
studies on this organism and shed light on how lower eukaryotic cells respond to low temperature. |
| first_indexed | 2025-11-14T23:53:24Z |
| format | Article |
| id | oai:generic.eprints.org:8724 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:53:24Z |
| publishDate | 2015 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:87242016-12-14T06:48:00Z http://journalarticle.ukm.my/8724/ In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A. Glaciozyma antarctica is a psychrophilic yeast isolated from the Antarctic sea ice. In this study, we performed a de novo characterisation of molecular chaperones from G. antarctica genome datasets. A total of 7857 genes that code for various types of proteins have been predicted from the G. antarctica genome sequence. From these genes, we identified 89 possible molecular chaperones that matched known molecular chaperones from other organisms available in various databases such as Uniprot, Gene Ontology, cpnDB and NCBI. For an in-depth analysis of molecular functions, we used homologous clustering to transfer knowledge from unknown to known functions using Cluster Analysis of Sequences (CLANS) bioinformatics software. The results reveal 12 major groups of chaperones that contribute to the cold-adaptation mechanism through their molecular function, biological processes and cellular components. The findings lay the foundation for future functional genomics studies on this organism and shed light on how lower eukaryotic cells respond to low temperature. Penerbit Universiti Kebangsaan Malaysia 2015-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8724/1/44_1_26.pdf Nur Athirah, Y. and Abu Bakar, F.D. and Illias, R.M. and Mahadi, N.M. and Murad, A.M.A. (2015) In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones. Malaysian Applied Biology, 44 (1). pp. 161-165. ISSN 0126-8643 http://www.mabjournal.com/index.php?option=com_content&view=article&id=505&catid=59:current-view&Itemid=56 |
| spellingShingle | Nur Athirah, Y. Abu Bakar, F.D. Illias, R.M. Mahadi, N.M. Murad, A.M.A. In silico characterisation of the Glaciozyma antarctica Genome: mining the molecular chaperones |
| title | In silico characterisation of the Glaciozyma antarctica
Genome: mining the molecular chaperones |
| title_full | In silico characterisation of the Glaciozyma antarctica
Genome: mining the molecular chaperones |
| title_fullStr | In silico characterisation of the Glaciozyma antarctica
Genome: mining the molecular chaperones |
| title_full_unstemmed | In silico characterisation of the Glaciozyma antarctica
Genome: mining the molecular chaperones |
| title_short | In silico characterisation of the Glaciozyma antarctica
Genome: mining the molecular chaperones |
| title_sort | in silico characterisation of the glaciozyma antarctica
genome: mining the molecular chaperones |
| url | http://journalarticle.ukm.my/8724/ http://journalarticle.ukm.my/8724/ http://journalarticle.ukm.my/8724/1/44_1_26.pdf |