Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives
Four new 6-methoxy-tetrahydro-β-carboline derivatives (1-6- methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 2-6-methoxy-1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 3-6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and 4-2-methoxy-4-(6-methoxy-2,3,4,9-tetra...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universiti Kebangsaan Malaysia
2015
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| Online Access: | http://journalarticle.ukm.my/8244/ http://journalarticle.ukm.my/8244/1/18_T.B._Goh.pdf |
| _version_ | 1848811741491757056 |
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| author | Goh, T.B. Mordi, M.M. Mansor, S.M. |
| author_facet | Goh, T.B. Mordi, M.M. Mansor, S.M. |
| author_sort | Goh, T.B. |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Four new 6-methoxy-tetrahydro-β-carboline derivatives (1-6- methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 2-6-methoxy-1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 3-6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and 4-2-methoxy-4-(6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenol) were prepared via the Maillard reaction using 5-methoxytryptamine and various aldehydes in water. The synthesis reaction conditions were optimised in catalyst loading, temperature and time using LC-MS for optimum yields. Surface response methodology and contour plot was selected as an approach for optimisation. The optimum yield could be achieved below 50oC within 5 h at 7 mole % catalyst loading at yields > 70%. The β-carboline compounds produced were characterised using electrospray ionization mass spectrometry (ESI-MS) and electrospray tandem mass (ESI-MS/MS). The mass fragmentation patterns of this group of heterocyclic tetrahydro-ß-carboline compounds are described herein. |
| first_indexed | 2025-11-14T23:51:13Z |
| format | Article |
| id | oai:generic.eprints.org:8244 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:51:13Z |
| publishDate | 2015 |
| publisher | Universiti Kebangsaan Malaysia |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:82442016-12-14T06:46:39Z http://journalarticle.ukm.my/8244/ Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives Goh, T.B. Mordi, M.M. Mansor, S.M. Four new 6-methoxy-tetrahydro-β-carboline derivatives (1-6- methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 2-6-methoxy-1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 3-6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and 4-2-methoxy-4-(6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenol) were prepared via the Maillard reaction using 5-methoxytryptamine and various aldehydes in water. The synthesis reaction conditions were optimised in catalyst loading, temperature and time using LC-MS for optimum yields. Surface response methodology and contour plot was selected as an approach for optimisation. The optimum yield could be achieved below 50oC within 5 h at 7 mole % catalyst loading at yields > 70%. The β-carboline compounds produced were characterised using electrospray ionization mass spectrometry (ESI-MS) and electrospray tandem mass (ESI-MS/MS). The mass fragmentation patterns of this group of heterocyclic tetrahydro-ß-carboline compounds are described herein. Universiti Kebangsaan Malaysia 2015-01 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8244/1/18_T.B._Goh.pdf Goh, T.B. and Mordi, M.M. and Mansor, S.M. (2015) Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives. Sains Malaysiana, 44 (1). pp. 127-137. ISSN 0126-6039 http://www.ukm.my/jsm/ |
| spellingShingle | Goh, T.B. Mordi, M.M. Mansor, S.M. Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives |
| title | Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives |
| title_full | Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives |
| title_fullStr | Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives |
| title_full_unstemmed | Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives |
| title_short | Mass spectrometry (LC-MS-MS) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives |
| title_sort | mass spectrometry (lc-ms-ms) as a tool in the maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives |
| url | http://journalarticle.ukm.my/8244/ http://journalarticle.ukm.my/8244/ http://journalarticle.ukm.my/8244/1/18_T.B._Goh.pdf |