Electron microscopy studies of the effects of garlic extract against trichophyton rubrum
Trichophyton rubrum is one of dermatophytes that penetrates keratinized tissues such as skin, hair and nail of human and animals. Recently, antifungal drugs such as imodazole and triazole was found to cause side effects, toxicity to patients and also not very efficient due to resistance to these dru...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universiti Kebangsaan Malaysia
2013
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| Online Access: | http://journalarticle.ukm.my/6622/ http://journalarticle.ukm.my/6622/1/07_Farzad_Aala-1.pdf |
| _version_ | 1848811216982507520 |
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| author | Farzad Aala, Umi Kalsom Yusuf, Rosimah Nulit, |
| author_facet | Farzad Aala, Umi Kalsom Yusuf, Rosimah Nulit, |
| author_sort | Farzad Aala, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Trichophyton rubrum is one of dermatophytes that penetrates keratinized tissues such as skin, hair and nail of human and animals. Recently, antifungal drugs such as imodazole and triazole was found to cause side effects, toxicity to patients and also not very efficient due to resistance to these drugs. As an alternative, some plants extract had been used to treat dermatophytes. This studies was done using Garlic extract (Allium sativum) to evaluate its effects on the growth of hypha of Trichophyton using Electron miscroscopy. Garlic had been known to posses antimicrobial, antiinflammatory, antithrombotic and antitumor activities. This studies found that garlic extract as low as 4 mg/mL inhibit the growth of hypha. Scanning electron microscopy studies revealed that hypha treated with garlic extract showed shrinkage, flat and cell wall demolition, similar to hypha treated with allicin (positive control) having rough surface, shrinkage and distortion. The tip of hypa became large after treatment with garlic extract. Transmission electron microscopy studies also found that hypha treated with allicin display cell wall thickening, local thickening, destruction of cytoplasmic content, mean while hypha treated with garlic extract exhibited cell wall thickening, disordered hyphal tip and desolution of cytoplasmic compartments and similar with hypha treated with allicin. These results showed that garlic extract and pure allicin could be use as an alternative to treat dermatophytes. |
| first_indexed | 2025-11-14T23:42:53Z |
| format | Article |
| id | oai:generic.eprints.org:6622 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:42:53Z |
| publishDate | 2013 |
| publisher | Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:66222016-12-14T06:41:43Z http://journalarticle.ukm.my/6622/ Electron microscopy studies of the effects of garlic extract against trichophyton rubrum Farzad Aala, Umi Kalsom Yusuf, Rosimah Nulit, Trichophyton rubrum is one of dermatophytes that penetrates keratinized tissues such as skin, hair and nail of human and animals. Recently, antifungal drugs such as imodazole and triazole was found to cause side effects, toxicity to patients and also not very efficient due to resistance to these drugs. As an alternative, some plants extract had been used to treat dermatophytes. This studies was done using Garlic extract (Allium sativum) to evaluate its effects on the growth of hypha of Trichophyton using Electron miscroscopy. Garlic had been known to posses antimicrobial, antiinflammatory, antithrombotic and antitumor activities. This studies found that garlic extract as low as 4 mg/mL inhibit the growth of hypha. Scanning electron microscopy studies revealed that hypha treated with garlic extract showed shrinkage, flat and cell wall demolition, similar to hypha treated with allicin (positive control) having rough surface, shrinkage and distortion. The tip of hypa became large after treatment with garlic extract. Transmission electron microscopy studies also found that hypha treated with allicin display cell wall thickening, local thickening, destruction of cytoplasmic content, mean while hypha treated with garlic extract exhibited cell wall thickening, disordered hyphal tip and desolution of cytoplasmic compartments and similar with hypha treated with allicin. These results showed that garlic extract and pure allicin could be use as an alternative to treat dermatophytes. Universiti Kebangsaan Malaysia 2013-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6622/1/07_Farzad_Aala-1.pdf Farzad Aala, and Umi Kalsom Yusuf, and Rosimah Nulit, (2013) Electron microscopy studies of the effects of garlic extract against trichophyton rubrum. Sains Malaysiana, 42 (11). pp. 1585-1590. ISSN 0126-6039 http://www.ukm.my/jsm/ |
| spellingShingle | Farzad Aala, Umi Kalsom Yusuf, Rosimah Nulit, Electron microscopy studies of the effects of garlic extract against trichophyton rubrum |
| title | Electron microscopy studies of the effects of garlic extract
against trichophyton rubrum |
| title_full | Electron microscopy studies of the effects of garlic extract
against trichophyton rubrum |
| title_fullStr | Electron microscopy studies of the effects of garlic extract
against trichophyton rubrum |
| title_full_unstemmed | Electron microscopy studies of the effects of garlic extract
against trichophyton rubrum |
| title_short | Electron microscopy studies of the effects of garlic extract
against trichophyton rubrum |
| title_sort | electron microscopy studies of the effects of garlic extract
against trichophyton rubrum |
| url | http://journalarticle.ukm.my/6622/ http://journalarticle.ukm.my/6622/ http://journalarticle.ukm.my/6622/1/07_Farzad_Aala-1.pdf |