The role of reactive oxygen species in pressure-dependent myogenic tone
Myogenic tone is the response of the vascular smooth muscle to an increase in intraluminal pressure with vasoconstriction and with vasodilation when the pressure is decreased. Such myogenic tone contributes a level of physiological basal tone in response to neurohumoral stimuli. In spite of myogenic...
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| Format: | Article |
| Language: | English |
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penerbit ukm
2012
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| Online Access: | http://journalarticle.ukm.my/5611/ http://journalarticle.ukm.my/5611/1/JSKM%20bab%201.pdf |
| _version_ | 1848810884161339392 |
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| author | Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth, |
| author_facet | Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth, |
| author_sort | Satirah Zainalabidin, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Myogenic tone is the response of the vascular smooth muscle to an increase in intraluminal pressure with vasoconstriction and with vasodilation when the pressure is decreased. Such myogenic tone contributes a level of physiological basal tone in response to neurohumoral stimuli. In spite of myogenic tone discovery by Sir William Bayliss 100 years ago, questions still remain regarding the underlying signaling mechanism of the myogenic response. Studies have shown that increased intraluminal pressure or wall tension leads to membrane depolarization, voltage-operated calcium channel (VOCC), stretch-activated cation (SAC) channels, extracelullar matrix (ECM) and actin cytoskeleton. Recently, evidence has shown a potential role for reactive oxygen species (ROS) as a key signalling mediator in the genesis of myogenic tone. The identification of the primary mechanosensors in the initiation of pressure-dependent myogenic tone is essential as these components could be potential therapeutical targets in the future. |
| first_indexed | 2025-11-14T23:37:36Z |
| format | Article |
| id | oai:generic.eprints.org:5611 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:37:36Z |
| publishDate | 2012 |
| publisher | penerbit ukm |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:56112016-12-14T06:38:59Z http://journalarticle.ukm.my/5611/ The role of reactive oxygen species in pressure-dependent myogenic tone Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth, RA Public aspects of medicine Myogenic tone is the response of the vascular smooth muscle to an increase in intraluminal pressure with vasoconstriction and with vasodilation when the pressure is decreased. Such myogenic tone contributes a level of physiological basal tone in response to neurohumoral stimuli. In spite of myogenic tone discovery by Sir William Bayliss 100 years ago, questions still remain regarding the underlying signaling mechanism of the myogenic response. Studies have shown that increased intraluminal pressure or wall tension leads to membrane depolarization, voltage-operated calcium channel (VOCC), stretch-activated cation (SAC) channels, extracelullar matrix (ECM) and actin cytoskeleton. Recently, evidence has shown a potential role for reactive oxygen species (ROS) as a key signalling mediator in the genesis of myogenic tone. The identification of the primary mechanosensors in the initiation of pressure-dependent myogenic tone is essential as these components could be potential therapeutical targets in the future. penerbit ukm 2012 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5611/1/JSKM%20bab%201.pdf Satirah Zainalabidin, and Paul Coats, and Roger M. Wadsworth, (2012) The role of reactive oxygen species in pressure-dependent myogenic tone. Jurnal Sains Kesihatan Malaysia, 10 (1). pp. 1-11. ISSN 1675-8161 |
| spellingShingle | RA Public aspects of medicine Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth, The role of reactive oxygen species in pressure-dependent myogenic tone |
| title | The role of reactive oxygen species in pressure-dependent myogenic tone |
| title_full | The role of reactive oxygen species in pressure-dependent myogenic tone |
| title_fullStr | The role of reactive oxygen species in pressure-dependent myogenic tone |
| title_full_unstemmed | The role of reactive oxygen species in pressure-dependent myogenic tone |
| title_short | The role of reactive oxygen species in pressure-dependent myogenic tone |
| title_sort | role of reactive oxygen species in pressure-dependent myogenic tone |
| topic | RA Public aspects of medicine |
| url | http://journalarticle.ukm.my/5611/ http://journalarticle.ukm.my/5611/1/JSKM%20bab%201.pdf |